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| Bone morphogenetic protein receptor, type IA |
Ternary Complex Of Bmp-2 Bound To Bmpr-Ia-Ecd And Actrii-Ecd
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| Other names: |
Serine/threonine-protein kinase receptor R5, SKR5, Activin receptor-like kinase 3, ALK-3, CD292 antigen |
| Genetic data |
| Locus: |
Chr. 10 q22.3 |
| Gene code: |
HUGO code:BMPR1A |
| Gene type: |
Protein coding |
| Protein Structure/Function |
| Protein length: |
532 (Amino Acids) |
| Molecular Weight: |
60198 (Da) |
| Structure: |
Complex Between Bmp-2 And Two Bmp Receptor Ia Ectodomains |
| Protein type: |
Receptor serine/threonine kinase |
| Functions: |
Receptor binding |
| Domains: |
TM domain S/T domain, GS domain |
| Motifs: |
SP motif |
| Other |
| Taxa expressing: |
Homo sapiens: homologs: many metazoan phyla |
| Cell types: |
many; prostate. cornea, brain |
| Subcellular localization: |
Plasma membrane |
| Pathway(s): |
TGF beta signaling pathway (KEGG) Cytokine-cytokine receptor interaction (KEGG) |
| Enzymatic Data |
| Catalytic activity: |
ATP + (receptor-protein) = ADP + receptor-protein phosphate |
| Cofactor(s): |
Magnesium or manganese |
| Receptor/Ligand data |
| Agonists: |
BMP2, BMP6, BMP7, GDF6 |
| Antagonists: |
Noggin, Chordin |
| Medical/Biotechnological data |
| Diseases: |
Juvenile polyposis syndrome (JPS) Online 'Mendelian Inheritance in Man' (OMIM) 174900; Cowden disease (CD) Online 'Mendelian Inheritance in Man' (OMIM) 158350; Hereditary mixed polyposis syndrome 2 (HMPS2) Online 'Mendelian Inheritance in Man' (OMIM) 610069 |
The BMPR1A receptor binds BMP2 and BMP4. BMPR1A has also been designated as CD292 (cluster of differentiation 290).
BMP's repress WNT signaling to maintain stable stem cell populations. BMPR1A null mice died at embyonic day 8.0 without mesoderm specification, demonstrating its vital role in gastrulation.[1] It has been demonstrated in experiments using dominant negative BMPR1A chick embryos that BMPR1A plays a role in apoptosis and adipocyte development.[1] Using constitutively active forms of BMR1A it has been shown that it plays a role in cell differentiation.[1] Signals tranduced by the BMPR1A receptor are not essential for osteoblast formation or proliferation; however, BMPR1A is necessary for the extracellular matrix depostition by osteoblasts.[1] In the chick embryo, BMPR1A receptors are found in low levels in limb bud mesenchyme, a differing location to BMPR1B, supporting the differing roles they play in osteogenesis.[2]
[edit] Diseases
BMPR1A, SMAD4 and PTEN are responsible for Juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden's disease.
[edit] References
- ^ a b c d Mishina Y, Starbuck MW, Gentile MA, Fukuda T, Kasparcova V, Seedor JG, Hanks MC, Amling M, Pinero GJ, Harada S, Behringer RR (2004). "Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling". J. Biol. Chem. 279 (26): 27560–6. doi:10.1074/jbc.M404222200. PMID 15090551.
- ^ Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM (2005). "Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo". Proc. Natl. Acad. Sci. U.S.A. 102 (14): 5062–7. doi:10.1073/pnas.0500031102. PMID 15781876.
[edit] External links
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Proteins: clusters of differentiation (see also list of human clusters of differentiation) |
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| 1-50 |
CD1 ( a-c, 1A, 1D, 1E) - CD2 - CD3 ( γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 ( a) - CD9 - CD10 - CD11 ( a, b, c) - CD13 - CD14 - CD15 - CD16 ( A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 ( A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 ( a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 ( a, b, c, d, e, f) - CD50
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| 51-100 |
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 ( E, L, P) - CD63 - CD64 - CD66 ( a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 ( a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 ( a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
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| 101-150 |
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| 151-200 |
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 ( a, b, c) - CD157 - CD158 ( a, d, e, i, k) - CD159 ( a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 ( a, b) - CD168 - CD169 - CD170 - CD171 - CD172 ( a, b, g) - CD174 - CD177 - CD178 - CD179 ( a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
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| 201-250 |
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| 251-300 |
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| 301-350 |
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Cell signaling: TGF beta signaling pathway |
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| TGF beta superfamily of ligands |
TGF beta family ( TGF-β1, TGF-β2, TGF-β3)
Bone morphogenetic proteins ( BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15)
Growth differentiation factors ( GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15)
Other ( Activin A and B/ Inhibin A and B, Anti-müllerian hormone, Nodal)
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| TGF beta receptors |
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| Transducers/SMAD |
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| Ligand Inhibitors |
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| Coreceptors |
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| Other |
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