SEMA4D
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Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
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| PDB rendering based on 1olz. | ||||||||||||||
| Available structures: 1olz | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | SEMA4D; CD100; M-sema G; M-sema-G; SEMAJ; coll-4 | |||||||||||||
| External IDs | OMIM: 601866 MGI: 109244 HomoloGene: 21282 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 10507 | 20354 | ||||||||||||
| Ensembl | ENSG00000187764 | ENSMUSG00000021451 | ||||||||||||
| Uniprot | Q92854 | Q6GTM9 | ||||||||||||
| Refseq | NM_006378 (mRNA) NP_006369 (protein) |
NM_013660 (mRNA) NP_038688 (protein) |
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| Location | Chr 9: 91.18 - 91.3 Mb | Chr 13: 51.71 - 51.81 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D) also known as CD100 (Cluster of Differentiation 100), is a human gene.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Bougeret C, Mansur IG, Dastot H, et al. (1992). "Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation.". J. Immunol. 148 (2): 318–23. PMID 1530858.
- Hall KT, Boumsell L, Schultze JL, et al. (1996). "Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11780–5. PMID 8876214.
- Herold C, Elhabazi A, Bismuth G, et al. (1997). "CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion.". J. Immunol. 157 (12): 5262–8. PMID 8955171.
- Furuyama T, Inagaki S, Kosugi A, et al. (1997). "Identification of a novel transmembrane semaphorin expressed on lymphocytes.". J. Biol. Chem. 271 (52): 33376–81. PMID 8969198.
- Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. PMID 10520995.
- Kumanogoh A, Watanabe C, Lee I, et al. (2001). "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling.". Immunity 13 (5): 621–31. PMID 11114375.
- Elhabazi A, Delaire S, Bensussan A, et al. (2001). "Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis.". J. Immunol. 166 (7): 4341–7. PMID 11254687.
- Delaire S, Billard C, Tordjman R, et al. (2001). "Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration.". J. Immunol. 166 (7): 4348–54. PMID 11254688.
- Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.". Genes Dev. 16 (7): 836–45. doi:. PMID 11937491.
- Granziero L, Circosta P, Scielzo C, et al. (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes.". Blood 101 (5): 1962–9. doi:. PMID 12406905.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:. PMID 12539042.
- Ishida I, Kumanogoh A, Suzuki K, et al. (2004). "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses.". Int. Immunol. 15 (8): 1027–34. PMID 12882840.
- Love CA, Harlos K, Mavaddat N, et al. (2003). "The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D.". Nat. Struct. Biol. 10 (10): 843–8. doi:. PMID 12958590.
- Giraudon P, Vincent P, Vuaillat C, et al. (2004). "Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells.". J. Immunol. 172 (2): 1246–55. PMID 14707103.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Deaglio S, Vaisitti T, Bergui L, et al. (2005). "CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival.". Blood 105 (8): 3042–50. doi:. PMID 15613544.
- Conrotto P, Valdembri D, Corso S, et al. (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1.". Blood 105 (11): 4321–9. doi:. PMID 15632204.
- Basile JR, Afkhami T, Gutkind JS (2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.". Mol. Cell. Biol. 25 (16): 6889–98. doi:. PMID 16055703.
- Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.". Mol. Cell Proteomics 5 (2): 226–33. doi:. PMID 16263699.
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