IL18RAP
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Interleukin 18 receptor accessory protein
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| Identifiers | ||||||||||||||
| Symbol(s) | IL18RAP; ACPL; CDw218b; MGC120589; MGC120590 | |||||||||||||
| External IDs | OMIM: 604509 MGI: 1338888 HomoloGene: 2859 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 8807 | 16174 | ||||||||||||
| Ensembl | ENSG00000115607 | ENSMUSG00000026068 | ||||||||||||
| Uniprot | O95256 | Q0VBK3 | ||||||||||||
| Refseq | NM_003853 (mRNA) NP_003844 (protein) |
NM_010553 (mRNA) NP_034683 (protein) |
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| Location | Chr 2: 102.4 - 102.44 Mb | Chr 1: 40.46 - 40.49 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.[1]
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Born TL, Thomassen E, Bird TA, Sims JE (1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling.". J. Biol. Chem. 273 (45): 29445–50. PMID 9792649.
- Sareneva T, Julkunen I, Matikainen S (2000). "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells.". J. Immunol. 165 (4): 1933–8. PMID 10925275.
- Mee JB, Alam Y, Groves RW (2000). "Human keratinocytes constitutively produce but do not process interleukin-18.". Br. J. Dermatol. 143 (2): 330–6. PMID 10951141.
- Debets R, Timans JC, Churakowa T, et al. (2000). "IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.". J. Immunol. 165 (9): 4950–6. PMID 11046021.
- Salvati VM, MacDonald TT, Bajaj-Elliott M, et al. (2002). "Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease.". Gut 50 (2): 186–90. PMID 11788557.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Fukushima K, Ikehara Y, Yamashita K (2005). "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production.". J. Biol. Chem. 280 (18): 18056–62. doi:. PMID 15760905.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:. PMID 15815621.
- Fiszer D, Rozwadowska N, Rychlewski L, et al. (2008). "Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues.". Cytokine 39 (3): 178–83. doi:. PMID 17897836.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
