MST1R

From Wikipedia, the free encyclopedia

Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

Identifiers

MST1R; CDw136; PTK8; RON

External IDs

OMIM: 600168 MGI: 99614 HomoloGene: 1835

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • receptor activity • macrophage colony stimulating factor receptor activity • ATP binding • transferase activity
Cellular Component:	• stress fiber • plasma membrane • integral to plasma membrane
Biological Process:	• protein amino acid phosphorylation • cell motility • defense response • signal transduction • multicellular organismal development • single fertilization • positive regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002447 (mRNA)
NP_002438 (protein)

NM_009074 (mRNA)
NP_033100 (protein)

Location

Chr 3: 49.9 - 49.92 Mb

Chr 9: 107.76 - 107.78 Mb

Pubmed search

[1]

[2]

Macrophage stimulating 1 receptor (c-met-related tyrosine kinase), also known as MST1R, is a human gene.^[1]

[edit] References

^ Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase).

[edit] Further reading

Li BQ, Wang MH, Kung HF, et al. (1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor.". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076.
Wang MH, Ronsin C, Gesnel MC, et al. (1994). "Identification of the ron gene product as the receptor for the human macrophage stimulating protein.". Science 266 (5182): 117–9. PMID 7939629.
Gaudino G, Follenzi A, Naldini L, et al. (1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.". EMBO J. 13 (15): 3524–32. PMID 8062829.
Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.". Oncogene 8 (12): 3403–10. PMID 8247543.
Ronsin C, Muscatelli F, Mattei MG, Breathnach R (1993). "A novel putative receptor protein tyrosine kinase of the met family.". Oncogene 8 (5): 1195–202. PMID 8386824.
Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). "A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype.". Mol. Cell. Biol. 16 (10): 5518–26. PMID 8816464.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Iwama A, Yamaguchi N, Suda T (1997). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.". EMBO J. 15 (21): 5866–75. PMID 8918464.
Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility.". J. Clin. Invest. 99 (4): 701–9. PMID 9045873.
Follenzi A, Bakovic S, Gual P, et al. (2000). "Cross-talk between the proto-oncogenes Met and Ron.". Oncogene 19 (27): 3041–9. doi:10.1038/sj.onc.1203620. PMID 10871856.
Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). "Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo.". Oncogene 21 (41): 6382–6. doi:10.1038/sj.onc.1205783. PMID 12214279.
Chen YQ, Zhou YQ, Fu LH, et al. (2002). "Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais.". Carcinogenesis 23 (11): 1811–9. PMID 12419829.
Zhou YQ, He C, Chen YQ, et al. (2003). "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential.". Oncogene 22 (2): 186–97. doi:10.1038/sj.onc.1206075. PMID 12527888.
Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003). "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus.". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4580–5. doi:10.1073/pnas.0837136100. PMID 12676986.
Rampino T, Gregorini M, Soccio G, et al. (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma.". Am. J. Surg. Pathol. 27 (6): 779–85. PMID 12766581.
Penengo L, Rubin C, Yarden Y, Gaudino G (2003). "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor.". Oncogene 22 (24): 3669–79. doi:10.1038/sj.onc.1206585. PMID 12802274.
Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness.". Exp. Cell Res. 288 (2): 382–9. PMID 12915129.
Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration.". Dev. Cell 5 (2): 257–71. PMID 12919677.
Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation.". J. Biol. Chem. 279 (5): 3726–32. doi:10.1074/jbc.M309342200. PMID 14597639.
van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004). "Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.". Blood 103 (12): 4457–65. doi:10.1182/blood-2003-08-2713. PMID 14982882.