ICAM3
From Wikipedia, the free encyclopedia
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Intercellular adhesion molecule 3
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| PDB rendering based on 1t0p. | ||||||||||||||
| Available structures: 1t0p | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | ICAM3; CD50; CDW50; ICAM-R | |||||||||||||
| External IDs | OMIM: 146631 HomoloGene: 88479 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3385 | n/a | ||||||||||||
| Ensembl | ENSG00000076662 | n/a | ||||||||||||
| Uniprot | P32942 | n/a | ||||||||||||
| Refseq | NM_002162 (mRNA) NP_002153 (protein) |
n/a (mRNA) n/a (protein) |
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| Location | Chr 19: 10.31 - 10.31 Mb | n/a | ||||||||||||
| Pubmed search | [1] | n/a | ||||||||||||
Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a human gene.
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Simmons DL (1995). "The role of ICAM expression in immunity and disease.". Cancer Surv. 24: 141–55. PMID 7553659.
- Hayflick JS, Kilgannon P, Gallatin WM (1998). "The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions.". Immunol. Res. 17 (3): 313–27. PMID 9638475.
- Fawcett J, Holness CL, Needham LA, et al. (1992). "Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes.". Nature 360 (6403): 481–4. doi:. PMID 1448173.
- Vazeux R, Hoffman PA, Tomita JK, et al. (1992). "Cloning and characterization of a new intercellular adhesion molecule ICAM-R.". Nature 360 (6403): 485–8. doi:. PMID 1448174.
- Pino-Otín MR, Juan M, de la Fuente MA, et al. (1995). "CD50 (intercellular adhesion molecule-3) is expressed at higher levels on memory than on naive human T cells but induces a similar calcium mobilization on both subsets.". Tissue Antigens 46 (1): 32–44. PMID 7482494.
- Marazuela M, Postigo AA, Acevedo A, et al. (1994). "Adhesion molecules from the LFA-1/ICAM-1,3 and VLA-4/VCAM-1 pathways on T lymphocytes and vascular endothelium in Graves' and Hashimoto's thyroid glands.". Eur. J. Immunol. 24 (10): 2483–90. PMID 7523142.
- Holness CL, Bates PA, Little AJ, et al. (1995). "Analysis of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated antigen 1.". J. Biol. Chem. 270 (2): 877–84. PMID 7822326.
- Martin S, Rieckmann P, Melchers I, et al. (1995). "Circulating forms of ICAM-3 (cICAM-3). Elevated levels in autoimmune diseases and lack of association with cICAM-1.". J. Immunol. 154 (4): 1951–5. PMID 7836774.
- Bossy D, Mattei MG, Simmons DL (1995). "The human intercellular adhesion molecule 3 (ICAM3) gene is located in the 19p13.2-p13.3 region, close to the ICAM1 gene.". Genomics 23 (3): 712–3. doi:. PMID 7851905.
- Skubitz KM, Ahmed K, Campbell KD, Skubitz AP (1995). "CD50 (ICAM-3) is phosphorylated on tyrosine and is associated with tyrosine kinase activity in human neutrophils.". J. Immunol. 154 (6): 2888–95. PMID 7876557.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
- Juan M, Vilella R, Mila J, et al. (1993). "CDw50 and ICAM-3: two names for the same molecule.". Eur. J. Immunol. 23 (7): 1508–12. PMID 8325327.
- de Fougerolles AR, Klickstein LB, Springer TA (1993). "Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1.". J. Exp. Med. 177 (4): 1187–92. PMID 8459213.
- Hosaka S, Shah MR, Pope RM, Koch AE (1996). "Soluble forms of P-selectin and intercellular adhesion molecule-3 in synovial fluids.". Clin. Immunol. Immunopathol. 78 (3): 276–82. PMID 8605703.
- Van der Vieren M, Le Trong H, Wood CL, et al. (1996). "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.". Immunity 3 (6): 683–90. PMID 8777714.
- Hayflick JS, Stine J, Fox R, et al. (1997). "Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residues.". J. Biol. Chem. 272 (35): 22207–14. PMID 9268366.
- Serrador JM, Alonso-Lebrero JL, del Pozo MA, et al. (1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization.". J. Cell Biol. 138 (6): 1409–23. PMID 9298994.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
- Bernstein CN, Sargent M, Gallatin WM (1998). "Beta2 integrin/ICAM expression in Crohn's disease.". Clin. Immunol. Immunopathol. 86 (2): 147–60. PMID 9473377.
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