LAIR1
From Wikipedia, the free encyclopedia
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Leukocyte-associated immunoglobulin-like receptor 1
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| Identifiers | ||||||||||||||
| Symbol(s) | LAIR1; CD305; LAIR-1 | |||||||||||||
| External IDs | OMIM: 602992 MGI: 105492 HomoloGene: 48097 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3903 | 52855 | ||||||||||||
| Ensembl | ENSG00000167613 | ENSMUSG00000055541 | ||||||||||||
| Uniprot | Q6GTX8 | Q8BG84 | ||||||||||||
| Refseq | NM_002287 (mRNA) NP_002278 (protein) |
NM_178611 (mRNA) NP_848726 (protein) |
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| Location | Chr 19: 59.56 - 59.57 Mb | Chr 7: 3.61 - 3.67 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Leukocyte-associated immunoglobulin-like receptor 1, also known as LAIR1, is a human gene.[1] LAIR1 has also been designated as CD305 (cluster of differentiation 305).
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[1]
[edit] References
[edit] Further reading
- Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. PMID 10404045.
- Meyaard L (1999). "LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells.". Curr. Top. Microbiol. Immunol. 244: 151–7. PMID 10453657.
- Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR).". J. Biol. Regul. Homeost. Agents 17 (4): 330–3. PMID 15065762.
- Meyaard L, Adema GJ, Chang C, et al. (1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.". Immunity 7 (2): 283–90. PMID 9285412.
- Poggi A, Tomasello E, Ferrero E, et al. (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor.". Eur. J. Immunol. 28 (7): 2086–91. PMID 9692876.
- Meyaard L, Hurenkamp J, Clevers H, et al. (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.". J. Immunol. 162 (10): 5800–4. PMID 10229813.
- van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling.". Eur. J. Immunol. 29 (10): 3160–7. PMID 10540327.
- Xu M, Zhao R, Zhao ZJ (2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells.". J. Biol. Chem. 275 (23): 17440–6. doi:. PMID 10764762.
- Poggi A, Pellegatta F, Leone BE, et al. (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias.". Eur. J. Immunol. 30 (10): 2751–8. PMID 11069054.
- Sathish JG, Johnson KG, Fuller KJ, et al. (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells.". J. Immunol. 166 (3): 1763–70. PMID 11160222.
- Meyaard L, van der Vuurst de Vries AR, de Ruiter T, et al. (2001). "The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR).". J. Exp. Med. 194 (1): 107–12. PMID 11435477.
- Saverino D, Fabbi M, Merlo A, et al. (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions.". Hum. Immunol. 63 (7): 534–46. PMID 12072189.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Aoukaty A, Lee IF, Wu J, Tan R (2004). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells.". J. Clin. Immunol. 23 (2): 141–5. PMID 12757266.
- Verbrugge A, Ruiter Td T, Clevers H, Meyaard L (2004). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment.". Int. Immunol. 15 (11): 1349–58. PMID 14565933.
- De Milito A, Nilsson A, Titanji K, et al. (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection.". Blood 103 (6): 2180–6. doi:. PMID 14604962.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
