CD133

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CD133 is a glycoprotein also known in humans and rodents as Prominin 1 (PROM1).^[1] It is the founding member of pentaspan transmembrane glycoproteins (5-transmembrane, 5-TM), which specifically localizes to cellular protrusions. CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastomas, neuronal and glial stem cells and some other cell types.^[2][3]

[edit] References

1. ^ Corbeil D, Fargeas C, Huttner W (2001). "Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein". Biochem Biophys Res Commun 285 (4): 939–44. doi:10.1006/bbrc.2001.5271. PMID 11467842. 
2. ^ Corbeil D, Röper K, Hellwig A, Tavian M, Miraglia S, Watt S, Simmons P, Peault B, Buck D, Huttner W (2000). "The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions". J Biol Chem 275 (8): 5512–20. doi:10.1074/jbc.275.8.5512. PMID 10681530. 
3. ^ Shmelkov S, St Clair R, Lyden D, Rafii S (2005). "AC133/CD133/Prominin-1". Int J Biochem Cell Biol 37 (4): 715–9. doi:10.1016/j.biocel.2004.08.010. PMID 15694831. 

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