NT5E
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5'-nucleotidase, ecto (CD73)
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| Identifiers | ||||||||||||||
| Symbol(s) | NT5E; CD73; E5NT; NT; NT5; NTE; eN; eNT | |||||||||||||
| External IDs | OMIM: 129190 MGI: 99782 HomoloGene: 1895 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 4907 | 23959 | ||||||||||||
| Ensembl | ENSG00000135318 | ENSMUSG00000032420 | ||||||||||||
| Uniprot | P21589 | Q0VEE0 | ||||||||||||
| Refseq | NM_002526 (mRNA) NP_002517 (protein) |
NM_011851 (mRNA) NP_035981 (protein) |
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| Location | Chr 6: 86.22 - 86.26 Mb | Chr 9: 88.13 - 88.17 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
5'-nucleotidase, ecto (NT5E), also known as CD73 (Cluster of Differentiation 73), is a human gene.[1]
Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.[supplied by OMIM][1]
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[edit] See also
[edit] References
[edit] Further reading
- Resta R, Thompson LF (1997). "T cell signalling through CD73.". Cell. Signal. 9 (2): 131–9. PMID 9113412.
- Kirchhoff C, Hale G (1997). "Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation.". Mol. Hum. Reprod. 2 (3): 177–84. PMID 9238677.
- Resta R, Yamashita Y, Thompson LF (1998). "Ecto-enzyme and signaling functions of lymphocyte CD73.". Immunol. Rev. 161: 95–109. PMID 9553767.
- Rosi F, Carlucci F, Marinello E, Tabucchi A (2002). "Ecto-5'-nucleotidase in B-cell chronic lymphocytic leukemia.". Biomed. Pharmacother. 56 (2): 100–4. PMID 12000134.
- Babiychuk EB, Draeger A (2006). "Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement?". Biochem. Soc. Trans. 34 (Pt 3): 374–6. doi:. PMID 16709165.
- Stefanovic V, Mandel P, Rosenberg A (1976). "Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells.". J. Biol. Chem. 251 (13): 3900–5. PMID 819433.
- Misumi Y, Ogata S, Ohkubo K, et al. (1990). "Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form.". Eur. J. Biochem. 191 (3): 563–9. PMID 2129526.
- Thomson LF, Ruedi JM, Glass A, et al. (1990). "Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73).". Tissue Antigens 35 (1): 9–19. PMID 2137649.
- Klemens MR, Sherman WR, Holmberg NJ, et al. (1990). "Characterization of soluble vs membrane-bound human placental 5'-nucleotidase.". Biochem. Biophys. Res. Commun. 172 (3): 1371–7. PMID 2173922.
- Boyle JM, Hey Y, Guerts van Kessel A, Fox M (1989). "Assignment of ecto-5'-nucleotidase to human chromosome 6.". Hum. Genet. 81 (1): 88–92. PMID 2848759.
- Vlahović P, Stefanović V (1995). "Effect of dopamine on ecto-5'-nucleotidase expression in human glomerular mesangial cells.". Archives internationales de physiologie, de biochimie et de biophysique 102 (3): 171–3. PMID 8000038.
- Hansen KR, Resta R, Webb CF, Thompson LF (1996). "Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene.". Gene 167 (1-2): 307–12. PMID 8566797.
- Airas L, Jalkanen S (1996). "CD73 mediates adhesion of B cells to follicular dendritic cells.". Blood 88 (5): 1755–64. PMID 8781432.
- Airas L, Niemelä J, Salmi M, et al. (1997). "Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells.". J. Cell Biol. 136 (2): 421–31. PMID 9015312.
- Strohmeier GR, Lencer WI, Patapoff TW, et al. (1997). "Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.". J. Clin. Invest. 99 (11): 2588–601. PMID 9169488.
- Aumüller G, Renneberg H, Schiemann PJ, et al. (1998). "The role of apocrine released proteins in the post-testicular regulation of human sperm function.". Adv. Exp. Med. Biol. 424: 193–219. PMID 9361795.
- Rosi F, Agostinho AB, Carlucci F, et al. (1998). "Behaviour of human lymphocytic isoenzymes of 5'-nucleotidase.". Life Sci. 62 (25): 2257–66. PMID 9651114.
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