PVRL3
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Poliovirus receptor-related 3
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| Identifiers | ||||||||||||||
| Symbol(s) | PVRL3; CDw113; DKFZP566B0846; FLJ90624; PPR3; PRR3; PVRR3; nectin-3 | |||||||||||||
| External IDs | OMIM: 607147 HomoloGene: 9162 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 25945 | n/a | ||||||||||||
| Ensembl | ENSG00000177707 | n/a | ||||||||||||
| Uniprot | Q9NQS3 | n/a | ||||||||||||
| Refseq | NM_015480 (mRNA) NP_056295 (protein) |
n/a (mRNA) n/a (protein) |
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| Location | Chr 3: 112.27 - 112.4 Mb | n/a | ||||||||||||
| Pubmed search | [1] | n/a | ||||||||||||
Poliovirus receptor-related 3, also known as PVRL3 and CD113 (Cluster of Differentiation 113), is a human gene.[1]
Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM][1]
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[edit] See also
[edit] References
[edit] Further reading
- Satoh-Horikawa K, Nakanishi H, Takahashi K, et al. (2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities.". J. Biol. Chem. 275 (14): 10291-9. PMID 10744716.
- Reymond N, Borg JP, Lecocq E, et al. (2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin.". Gene 255 (2): 347-55. PMID 11024295.
- Fabre S, Reymond N, Cocchi F, et al. (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain.". J. Biol. Chem. 277 (30): 27006-13. doi:. PMID 12011057.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Takekuni K, Ikeda W, Fujito T, et al. (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse.". J. Biol. Chem. 278 (8): 5497-500. doi:. PMID 12515806.
- Mueller S, Wimmer E (2003). "Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains.". J. Biol. Chem. 278 (33): 31251-60. doi:. PMID 12759359.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:. PMID 16189514.
- Fujito T, Ikeda W, Kakunaga S, et al. (2005). "Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3.". J. Cell Biol. 171 (1): 165-73. doi:. PMID 16216929.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
