Leptin receptor
From Wikipedia, the free encyclopedia
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Leptin receptor
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| Identifiers | ||||||||||||||
| Symbol(s) | LEPR; CD295; OBR | |||||||||||||
| External IDs | OMIM: 601007 MGI: 104993 HomoloGene: 1731 | |||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3953 | 16847 | ||||||||||||
| Ensembl | n/a | ENSMUSG00000057722 | ||||||||||||
| Uniprot | n/a | P48356 | ||||||||||||
| Refseq | NM_001003679 (mRNA) NP_001003679 (protein) |
NM_010704 (mRNA) NP_034834 (protein) |
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| Location | n/a | Chr 4: 101.22 - 101.31 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Leptin receptor, also known as LEPR, is a human gene. LEPR has also been designated as CD295 (cluster of differentiation 295).
Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM][1]
[edit] References
[edit] Further reading
- Heshka JT, Jones PJ (2001). "A role for dietary fat in leptin receptor, OB-Rb, function.". Life Sci. 69 (9): 987-1003. PMID 11508653.
- Tartaglia LA, Dembski M, Weng X, et al. (1996). "Identification and expression cloning of a leptin receptor, OB-R.". Cell 83 (7): 1263-71. PMID 8548812.
- Chen H, Charlat O, Tartaglia LA, et al. (1996). "Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.". Cell 84 (3): 491-5. PMID 8608603.
- Cioffi JA, Shafer AW, Zupancic TJ, et al. (1996). "Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction.". Nat. Med. 2 (5): 585-9. PMID 8616721.
- Considine RV, Considine EL, Williams CJ, et al. (1996). "The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations.". Diabetes 45 (7): 992-4. PMID 8666155.
- Chung WK, Power-Kehoe L, Chua M, Leibel RL (1996). "Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human.". Genome Res. 6 (5): 431-8. PMID 8743992.
- Bennett BD, Solar GP, Yuan JQ, et al. (1997). "A role for leptin and its cognate receptor in hematopoiesis.". Curr. Biol. 6 (9): 1170-80. PMID 8805376.
- Winick JD, Stoffel M, Friedman JM (1997). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1.". Genomics 36 (1): 221-2. doi:. PMID 8812446.
- Luoh SM, Di Marco F, Levin N, et al. (1997). "Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin.". J. Mol. Endocrinol. 18 (1): 77-85. PMID 9061609.
- Echwald SM, Sørensen TD, Sørensen TI, et al. (1997). "Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.". Biochem. Biophys. Res. Commun. 233 (1): 248-52. doi:. PMID 9144432.
- Thompson DB, Ravussin E, Bennett PH, Bogardus C (1997). "Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians.". Hum. Mol. Genet. 6 (5): 675-9. PMID 9158141.
- Gotoda T, Manning BS, Goldstone AP, et al. (1997). "Leptin receptor gene variation and obesity: lack of association in a white British male population.". Hum. Mol. Genet. 6 (6): 869-76. PMID 9175732.
- Bailleul B, Akerblom I, Strosberg AD (1997). "The leptin receptor promoter controls expression of a second distinct protein.". Nucleic Acids Res. 25 (14): 2752-8. PMID 9207021.
- Chung WK, Power-Kehoe L, Chua M, et al. (1997). "Exonic and intronic sequence variation in the human leptin receptor gene (LEPR).". Diabetes 46 (9): 1509-11. PMID 9287054.
- Bjørbaek C, Uotani S, da Silva B, Flier JS (1998). "Divergent signaling capacities of the long and short isoforms of the leptin receptor.". J. Biol. Chem. 272 (51): 32686-95. PMID 9405487.
- Clément K, Vaisse C, Lahlou N, et al. (1998). "A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.". Nature 392 (6674): 398-401. doi:. PMID 9537324.
- Carpenter LR, Farruggella TJ, Symes A, et al. (1998). "Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6061-6. PMID 9600917.
- Kielar D, Clark JS, Ciechanowicz A, et al. (1998). "Leptin receptor isoforms expressed in human adipose tissue.". Metab. Clin. Exp. 47 (7): 844-7. PMID 9667233.
- Haniu M, Arakawa T, Bures EJ, et al. (1998). "Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.". J. Biol. Chem. 273 (44): 28691-9. PMID 9786864.
- Haft CR, de la Luz Sierra M, Barr VA, et al. (1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors.". Mol. Cell. Biol. 18 (12): 7278-87. PMID 9819414.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
