CD9
From Wikipedia, the free encyclopedia
|
CD9 molecule
|
||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | CD9; 5H9; BA2; BTCC-1; DRAP-27; GIG2; MIC3; MRP-1; P24; TSPAN29 | |||||||||||||
| External IDs | OMIM: 143030 MGI: 88348 HomoloGene: 20420 | |||||||||||||
|
||||||||||||||
| RNA expression pattern | ||||||||||||||
|
|
||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 928 | 12527 | ||||||||||||
| Ensembl | ENSG00000010278 | ENSMUSG00000030342 | ||||||||||||
| Uniprot | P21926 | P40240 | ||||||||||||
| Refseq | NM_001769 (mRNA) NP_001760 (protein) |
NM_007657 (mRNA) NP_031683 (protein) |
||||||||||||
| Location | Chr 12: 6.18 - 6.22 Mb | Chr 6: 125.43 - 125.46 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD9 molecule, also known as CD9, is a human gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance.[1]
[edit] See also
[edit] References
[edit] Further reading
- Horejsí V, Vlcek C (1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63.". FEBS Lett. 288 (1-2): 1–4. PMID 1879540.
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
- Ninomiya H, Sims PJ (1992). "The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9.". J. Biol. Chem. 267 (19): 13675–80. PMID 1377690.
- Miyake M, Koyama M, Seno M, Ikeyama S (1992). "Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility.". J. Exp. Med. 174 (6): 1347–54. PMID 1720807.
- Boucheix C, Benoit P, Frachet P, et al. (1991). "Molecular cloning of the CD9 antigen. A new family of cell surface proteins.". J. Biol. Chem. 266 (1): 117–22. PMID 1840589.
- Iwamoto R, Senoh H, Okada Y, et al. (1991). "An antibody that inhibits the binding of diphtheria toxin to cells revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor.". J. Biol. Chem. 266 (30): 20463–9. PMID 1939101.
- Benoit P, Gross MS, Frachet P, et al. (1991). "Assignment of the human CD9 gene to chromosome 12 (region P13) by use of human specific DNA probes.". Hum. Genet. 86 (3): 268–72. PMID 1997380.
- Lanza F, Wolf D, Fox CF, et al. (1991). "cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins.". J. Biol. Chem. 266 (16): 10638–45. PMID 2037603.
- Higashihara M, Takahata K, Yatomi Y, et al. (1990). "Purification and partial characterization of CD9 antigen of human platelets.". FEBS Lett. 264 (2): 270–4. PMID 2358073.
- Katz F, Povey S, Parkar M, et al. (1984). "Chromosome assignment of monoclonal antibody-defined determinants on human leukemic cells.". Eur. J. Immunol. 13 (12): 1008–13. PMID 6198179.
- Masellis-Smith A, Shaw AR (1994). "CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin.". J. Immunol. 152 (6): 2768–77. PMID 7511626.
- Chalupny NJ, Kanner SB, Schieven GL, et al. (1993). "Tyrosine phosphorylation of CD19 in pre-B and mature B cells.". EMBO J. 12 (7): 2691–6. PMID 7687539.
- Ikeyama S, Koyama M, Yamaoko M, et al. (1993). "Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA.". J. Exp. Med. 177 (5): 1231–7. PMID 8478605.
- Rubinstein E, Benoit P, Billard M, et al. (1993). "Organization of the human CD9 gene.". Genomics 16 (1): 132–8. doi:. PMID 8486348.
- Radford KJ, Thorne RF, Hersey P (1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma.". Biochem. Biophys. Res. Commun. 222 (1): 13–8. doi:. PMID 8630057.
- Schmidt C, Künemund V, Wintergerst ES, et al. (1996). "CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the alpha 6/beta 1 integrin and the neural adhesion molecule L1.". J. Neurosci. Res. 43 (1): 12–31. doi:. PMID 8838570.
- Sincock PM, Mayrhofer G, Ashman LK (1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin.". J. Histochem. Cytochem. 45 (4): 515–25. PMID 9111230.
- Rubinstein E, Poindessous-Jazat V, Le Naour F, et al. (1997). "CD9, but not other tetraspans, associates with the beta1 integrin precursor.". Eur. J. Immunol. 27 (8): 1919–27. PMID 9295027.
- Tachibana I, Bodorova J, Berditchevski F, et al. (1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins.". J. Biol. Chem. 272 (46): 29181–9. PMID 9360996.
 |
This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it. |
