VE-cadherin
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Cadherin 5, type 2, VE-cadherin (vascular epithelium)
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| Identifiers | ||||||||||||||
| Symbol(s) | CDH5; 7B4; CD144 | |||||||||||||
| External IDs | OMIM: 601120 MGI: 105057 HomoloGene: 1359 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1003 | 12562 | ||||||||||||
| Ensembl | ENSG00000179776 | ENSMUSG00000031871 | ||||||||||||
| Uniprot | P33151 | Q3TJ23 | ||||||||||||
| Refseq | NM_001795 (mRNA) NP_001786 (protein) |
NM_009868 (mRNA) NP_033998 (protein) |
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| Location | Chr 16: 64.96 - 65 Mb | Chr 8: 106.99 - 107.03 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Cadherin 5, type 2 or VE-cadherin (vascular epithelium) also known as CD144 (Cluster of Differentiation 144), is a type of cadherin. It is encoded by the human gene CDH5.
It is a classical cadherin from the cadherin superfamily and the gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.[1]
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[edit] References
[edit] See also
[edit] Further reading
- Lampugnani MG, Resnati M, Raiteri M, et al. (1992). "A novel endothelial-specific membrane protein is a marker of cell-cell contacts.". J. Cell Biol. 118 (6): 1511–22. PMID 1522121.
- Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.". Cell Regul. 2 (4): 261–70. PMID 2059658.
- Breviario F, Caveda L, Corada M, et al. (1995). "Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin.". Arterioscler. Thromb. Vasc. Biol. 15 (8): 1229–39. PMID 7627717.
- Ali J, Liao F, Martens E, Muller WA (1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion.". Microcirculation (New York, N.Y. : 1994) 4 (2): 267–77. PMID 9219219.
- Lampugnani MG, Corada M, Andriopoulou P, et al. (1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells.". J. Cell. Sci. 110 ( Pt 17): 2065–77. PMID 9378757.
- Lewalle JM, Bajou K, Desreux J, et al. (1998). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro.". Exp. Cell Res. 237 (2): 347–56. doi:. PMID 9434630.
- Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:. PMID 9615235.
- Kowalczyk AP, Navarro P, Dejana E, et al. (1998). "VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions.". J. Cell. Sci. 111 ( Pt 20): 3045–57. PMID 9739078.
- Kawashima M, Kitagawa M (1999). "An immunohistochemical study of cadherin 5 (VE-cadherin) in vascular endothelial cells in placentas with gestosis.". J. Obstet. Gynaecol. Res. 24 (6): 375–84. PMID 10063232.
- Carmeliet P, Lampugnani MG, Moons L, et al. (1999). "Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.". Cell 98 (2): 147–57. PMID 10428027.
- Ukropec JA, Hollinger MK, Salva SM, Woolkalis MJ (2000). "SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin.". J. Biol. Chem. 275 (8): 5983–6. PMID 10681592.
- Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.". Biochem. J. 349 (Pt 1): 159–67. PMID 10861224.
- Shaw SK, Bamba PS, Perkins BN, Luscinskas FW (2001). "Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium.". J. Immunol. 167 (4): 2323–30. PMID 11490021.
- van Buul JD, Voermans C, van den Berg V, et al. (2002). "Migration of human hematopoietic progenitor cells across bone marrow endothelium is regulated by vascular endothelial cadherin.". J. Immunol. 168 (2): 588–96. PMID 11777950.
- Ferber A, Yaen C, Sarmiento E, Martinez J (2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation.". Exp. Cell Res. 274 (1): 35–44. doi:. PMID 11855855.
- Gorlatov S, Medved L (2002). "Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains.". Biochemistry 41 (12): 4107–16. PMID 11900554.
- Di Simone N, Castellani R, Caliandro D, Caruso A (2003). "Antiphospholid antibodies regulate the expression of trophoblast cell adhesion molecules.". Fertil. Steril. 77 (4): 805–11. PMID 11937138.
- Zanetti A, Lampugnani MG, Balconi G, et al. (2002). "Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling.". Arterioscler. Thromb. Vasc. Biol. 22 (4): 617–22. PMID 11950700.
- Lampugnani MG, Zanetti A, Breviario F, et al. (2002). "VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam.". Mol. Biol. Cell 13 (4): 1175–89. doi:. PMID 11950930.
- Shasby DM, Ries DR, Shasby SS, Winter MC (2002). "Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin.". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (6): L1330–8. doi:. PMID 12003790.
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