SIRPG
From Wikipedia, the free encyclopedia
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Signal-regulatory protein gamma
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| Identifiers | |||||||||||
| Symbol(s) | SIRPG; CD172g; SIRP-B2; SIRPB2; SIRPgamma; bA77C3.1 | ||||||||||
| External IDs | OMIM: 605466 HomoloGene: 56809 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 55423 | n/a | |||||||||
| Ensembl | ENSG00000089012 | n/a | |||||||||
| Uniprot | Q9P1W8 | n/a | |||||||||
| Refseq | NM_001039508 (mRNA) NP_001034597 (protein) |
n/a (mRNA) n/a (protein) |
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| Location | Chr 20: 1.56 - 1.59 Mb | n/a | |||||||||
| Pubmed search | [1] | n/a | |||||||||
Signal-regulatory protein gamma, also known as SIRPG, is a human gene.[1] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.[1]
[edit] References
[edit] Further reading
- Kharitonenkov A, Chen Z, Sures I, et al. (1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors.". Nature 386 (6621): 181–6. doi:. PMID 9062191.
- Ichigotani Y, Matsuda S, Machida K, et al. (2001). "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family.". J. Hum. Genet. 45 (6): 378–82. PMID 11185750.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Brooke G, Holbrook JD, Brown MH, Barclay AN (2004). "Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family.". J. Immunol. 173 (4): 2562–70. PMID 15294972.
- Piccio L, Vermi W, Boles KS, et al. (2006). "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.". Blood 105 (6): 2421–7. doi:. PMID 15383453.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- van den Berg TK, van Beek EM, Bühring HJ, et al. (2006). "A nomenclature for signal regulatory protein family members.". J. Immunol. 175 (12): 7788–9. PMID 16339511.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:. PMID 16344560.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
