CD79A
From Wikipedia, the free encyclopedia
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CD79a molecule, immunoglobulin-associated alpha
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| Identifiers | ||||||||||||||
| Symbol(s) | CD79A; IGA; MB-1 | |||||||||||||
| External IDs | OMIM: 112205 MGI: 101774 HomoloGene: 31053 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 973 | 12518 | ||||||||||||
| Ensembl | ENSG00000105369 | n/a | ||||||||||||
| Uniprot | P11912 | n/a | ||||||||||||
| Refseq | NM_001783 (mRNA) NP_001774 (protein) |
XM_989437 (mRNA) XP_994531 (protein) |
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| Location | Chr 19: 47.07 - 47.08 Mb | n/a | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD79a molecule, immunoglobulin-associated alpha, also known as CD79A (Cluster of Differentiation 79A), is a human gene.[1]
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Reth M (1992). "Antigen receptors on B lymphocytes.". Annu. Rev. Immunol. 10: 97–121. doi:. PMID 1591006.
- Herren B, Burrows PD (2003). "B cell-restricted human mb-1 gene: expression, function, and lineage infidelity.". Immunol. Res. 26 (1-3): 35–43. PMID 12403343.
- Bastian A, Kratzin H, Eckart K, Hilschmann N (1993). "Intra- and interchain disulfide bridges of the human J chain in secretory immunoglobulin A.". Biol. Chem. Hoppe-Seyler 373 (12): 1255–63. PMID 1292512.
- Leduc I, Preud'homme JL, Cogné M (1992). "Structure and expression of the mb-1 transcript in human lymphoid cells.". Clin. Exp. Immunol. 90 (1): 141–6. PMID 1395095.
- Kristensen T, Lopez R, Prydz H (1992). "An estimate of the sequencing error frequency in the DNA sequence databases.". DNA Seq. 2 (6): 343–6. PMID 1446073.
- Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.". Eur. J. Immunol. 22 (6): 1621–5. PMID 1534761.
- Ha HJ, Kubagawa H, Burrows PD (1992). "Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene.". J. Immunol. 148 (5): 1526–31. PMID 1538135.
- Hutchcroft JE, Harrison ML, Geahlen RL (1992). "Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.". J. Biol. Chem. 267 (12): 8613–9. PMID 1569106.
- Flaswinkel H, Reth M (1992). "Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex.". Immunogenetics 36 (4): 266–9. PMID 1639443.
- Yu LM, Chang TW (1992). "Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes.". J. Immunol. 148 (2): 633–7. PMID 1729378.
- Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS (1991). "The B-cell antigen receptor of the five immunoglobulin classes.". Nature 352 (6338): 777–81. doi:. PMID 1881434.
- Bakos MA, Kurosky A, Goldblum RM (1991). "Characterization of a critical binding site for human polymeric Ig on secretory component.". J. Immunol. 147 (10): 3419–26. PMID 1940346.
- Sakaguchi N, Kashiwamura S, Kimoto M, et al. (1989). "B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties.". EMBO J. 7 (11): 3457–64. PMID 2463161.
- Grubb AO, López C, Tejler L, Mendez E (1984). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration.". J. Biol. Chem. 258 (23): 14698–707. PMID 6196366.
- Kurosaki T, Johnson SA, Pao L, et al. (1996). "Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.". J. Exp. Med. 182 (6): 1815–23. PMID 7500027.
- Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex.". Eur. J. Immunol. 24 (4): 812–6. PMID 7512031.
- Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.". Mol. Immunol. 31 (6): 419–27. PMID 7514267.
- Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45.". J. Biol. Chem. 269 (25): 17238–44. PMID 7516335.
- Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.". J. Exp. Med. 181 (6): 2077–84. PMID 7539038.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
