LY9

From Wikipedia, the free encyclopedia

Lymphocyte antigen 9

Identifiers

LY9; CD229; SLAMF3; hly9; mLY9

External IDs

OMIM: 600684 MGI: 96885 HomoloGene: 1759

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• cell adhesion • immunoglobulin mediated immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001033667 (mRNA)
NP_001028839 (protein)

NM_008534 (mRNA)
NP_032560 (protein)

Location

Chr 1: 159.03 - 159.06 Mb

Chr 1: 173.43 - 173.44 Mb

Pubmed search

[1]

[2]

Lymphocyte antigen 9, also known as LY9, is a human gene.^[1] LY9 has also recently been designated CD229 (cluster of differentiation 229).

[edit] References

^ Entrez Gene: LY9 lymphocyte antigen 9.

[edit] Further reading

Kingsmore SF, Souryal CA, Watson ML, et al. (1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1.". Immunogenetics 42 (1): 59-62. PMID 7797269.
Sandrin MS, Henning MM, Lo MF, et al. (1996). "Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9.". Immunogenetics 43 (1-2): 13-9. PMID 8537117.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Tovar V, de la Fuente MA, Pizcueta P, et al. (2000). "Gene structure of the mouse leukocyte cell surface molecule Ly9.". Immunogenetics 51 (10): 788-93. PMID 10970093.
de la Fuente MA, Tovar V, Villamor N, et al. (2001). "Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9.". Blood 97 (11): 3513-20. PMID 11369645.
Sayós J, Martín M, Chen A, et al. (2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.". Blood 97 (12): 3867-74. PMID 11389028.
Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.". J. Biol. Chem. 276 (39): 36809-16. doi:10.1074/jbc.M101305200. PMID 11477068.
Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.". EMBO J. 20 (21): 5840-52. doi:10.1093/emboj/20.21.5840. PMID 11689425.
Tovar V, del Valle J, Zapater N, et al. (2002). "Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors.". Immunogenetics 54 (6): 394-402. doi:10.1007/s00251-002-0483-3. PMID 12242590.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).". J. Biol. Chem. 278 (19): 17430-7. doi:10.1074/jbc.M301569200. PMID 12621057.
Martín M, Del Valle JM, Saborit I, Engel P (2005). "Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229.". J. Immunol. 174 (10): 5977-86. PMID 15879090.
Romero X, Zapater N, Calvo M, et al. (2005). "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse.". J. Immunol. 174 (11): 7033-42. PMID 15905546.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.

[edit] External links

MeSH LY9+protein,+human

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50

51-100	CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100

101-150	CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150

151-200	CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200

201-250	CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249

251-300	CD252 - CD253 - CD254 - CD256 - CD257 - CD258 - CD261 - CD262 - CD264 - CD265 - CD266 - CD267 - CD268 - CD269 - CD271 - CD272 - CD273 - CD274 - CD275 - CD276 - CD278 - CD279 - CD280 - CD281 - CD282 - CD283 - CD284 - CD286 - CD288 - CD289 - CD290 - CD292 - CDw293 - CD294 - CD295 - CD297 - CD298 - CD299

301-350	CD300A - CD304 - CD305 - CD307 - CD309 - CD312 - CD314 - CD315 - CD316 - CD317 - CD318 - CD320 - CD321 - CD322 - CD324 - CD325 - CD326 - CD328 - CD329 - CD331 - CD332 - CD333 - CD334 - CD335 - CD336 - CD337 - CD338 - CD339 - CD340 - CD344 - CD349 - CD350