Retinoic acid receptor alpha

From Wikipedia, the free encyclopedia

Retinoic acid receptor, alpha

PDB rendering based on 1dkf.

Available structures: 1dkf, 1dsz, 1hra

Identifiers

Symbol(s)

RARA; NR1B1; RAR

External IDs

OMIM: 180240 MGI: 97856 HomoloGene: 20262

Gene ontology
Molecular Function:	• transcription factor activity • steroid hormone receptor activity • retinoic acid receptor activity • transcription coactivator activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001033603 (mRNA)
NP_001028775 (protein)

NM_009024 (mRNA)
NP_033050 (protein)

Location

Chr 17: 35.72 - 35.77 Mb

Chr 11: 98.75 - 98.79 Mb

Pubmed search

[1]

[2]

Retinoic acid receptor alpha (RAR-alpha), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor encoded by the RARA gene.

[edit] See also

Retinoic acid receptor

[edit] Further reading

Petkovich M, Brand NJ, Krust A, Chambon P (1988). "A human retinoic acid receptor which belongs to the family of nuclear receptors.". Nature 330 (6147): 444–50. doi:10.1038/330444a0. PMID 2825025.
Sirulnik A, Melnick A, Zelent A, Licht JD (2004). "Molecular pathogenesis of acute promyelocytic leukaemia and APL variants.". Best practice & research. Clinical haematology 16 (3): 387–408. PMID 12935958.
Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM (1992). "Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.". Nature 355 (6359): 446–9. doi:10.1038/355446a0. PMID 1310351.
Kastner P, Perez A, Lutz Y, et al. (1992). "Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.". EMBO J. 11 (2): 629–42. PMID 1311253.
Baniahmad A, Köhne AC, Renkawitz R (1992). "A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.". EMBO J. 11 (3): 1015–23. PMID 1347744.
de Thé H, Lavau C, Marchio A, et al. (1991). "The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.". Cell 66 (4): 675–84. PMID 1652369.
de Thé H, Chomienne C, Lanotte M, et al. (1990). "The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.". Nature 347 (6293): 558–61. doi:10.1038/347558a0. PMID 2170850.
Brand NJ, Petkovich M, Chambon P (1991). "Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha).". Nucleic Acids Res. 18 (23): 6799–806. PMID 2175878.
Borrow J, Goddard AD, Sheer D, Solomon E (1990). "Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.". Science 249 (4976): 1577–80. PMID 2218500.
Giguere V, Ong ES, Segui P, Evans RM (1988). "Identification of a receptor for the morphogen retinoic acid.". Nature 330 (6149): 624–9. doi:10.1038/330624a0. PMID 2825036.
Arveiler B, Petkovich M, Mandel JL, Chambon P (1988). "A PstI RFLP for the human retinoic acid receptor in 17q21.". Nucleic Acids Res. 16 (13): 6252. PMID 2899875.
Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors.". Nature 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127.
Fisher GJ, Talwar HS, Xiao JH, et al. (1994). "Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin.". J. Biol. Chem. 269 (32): 20629–35. PMID 8051161.
Anderson LA, Friedman L, Osborne-Lawrence S, et al. (1993). "High-density genetic map of the BRCA1 region of chromosome 17q12-q21.". Genomics 17 (3): 618–23. doi:10.1006/geno.1993.1381. PMID 8244378.
Chen Z, Guidez F, Rousselot P, et al. (1994). "PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1178–82. PMID 8302850.
Redner RL, Rush EA, Faas S, et al. (1996). "The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.". Blood 87 (3): 882–6. PMID 8562957.
Kamei Y, Xu L, Heinzel T, et al. (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.". Cell 85 (3): 403–14. PMID 8616895.
Liu W, Hellman P, Li Q, et al. (1997). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.". Biochem. Biophys. Res. Commun. 229 (3): 922–9. doi:10.1006/bbrc.1996.1903. PMID 9005841.
Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.". J. Biol. Chem. 272 (18): 12062–8. PMID 9115274.

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD

Categories: Genes on chromosome 17 | Human proteins | Chromosome 17 gene stubs | Intracellular receptors | Transcription factors

See also ebooksgratis.com: no banners, no cookies, totally FREE.

Retinoic acid receptor alpha

From Wikipedia, the free encyclopedia

[edit] See also

[edit] Further reading

Views

Navigation

Interaction

Search