IRF4

From Wikipedia, the free encyclopedia

Interferon regulatory factor 4

PDB rendering based on 2dll.

Available structures: 2dll

Identifiers

Symbol(s)

IRF4; LSIRF; MUM1

External IDs

OMIM: 601900 MGI: 1096873 HomoloGene: 1842

Gene ontology
Molecular Function:	• transcription factor activity • RNA polymerase II transcription factor activity • transcription factor binding • transcription activator activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • T cell activation • myeloid dendritic cell differentiation • positive regulation of interleukin-10 biosynthetic process • positive regulation of interleukin-2 biosynthetic process • positive regulation of interleukin-13 biosynthetic process • positive regulation of interleukin-4 biosynthetic process • regulation of T-helper cell differentiation • positive regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002460 (mRNA)
NP_002451 (protein)

NM_013674 (mRNA)
NP_038702 (protein)

Location

Chr 6: 0.34 - 0.36 Mb

Chr 13: 30.76 - 30.77 Mb

Pubmed search

[1]

[2]

Interferon regulatory factor 4, also known as IRF4, is a human gene.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Interferon regulatory factors

[edit] References

^ Entrez Gene: IRF4 interferon regulatory factor 4.

[edit] Further reading

Mamane Y, Sharma S, Grandvaux N, et al. (2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis.". J. Interferon Cytokine Res. 22 (1): 135–43. doi:10.1089/107999002753452746. PMID 11846984.
Yamagata T, Nishida J, Tanaka S, et al. (1996). "A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes.". Mol. Cell. Biol. 16 (4): 1283–94. PMID 8657101.
Grossman A, Mittrücker HW, Nicholl J, et al. (1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.". Genomics 37 (2): 229–33. doi:10.1006/geno.1996.0547. PMID 8921401.
Iida S, Rao PH, Butler M, et al. (1997). "Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma.". Nat. Genet. 17 (2): 226–30. doi:10.1038/ng1097-226. PMID 9326949.
Brass AL, Zhu AQ, Singh H (1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers.". EMBO J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMID 10022840.
Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.". J. Biol. Chem. 274 (16): 11115–24. PMID 10196196.
Marecki S, Atchison ML, Fenton MJ (1999). "Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages.". J. Immunol. 163 (5): 2713–22. PMID 10453013.
Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.". J. Exp. Med. 190 (12): 1837–48. PMID 10601358.
Mamane Y, Sharma S, Petropoulos L, et al. (2000). "Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52.". Immunity 12 (2): 129–40. PMID 10714679.
Gupta S, Anthony A, Pernis AB (2001). "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins.". J. Immunol. 166 (10): 6104–11. PMID 11342629.
Imaizumi Y, Kohno T, Yamada Y, et al. (2002). "Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia.". Jpn. J. Cancer Res. 92 (12): 1284–92. PMID 11749693.
Rengarajan J, Mowen KA, McBride KD, et al. (2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.". J. Exp. Med. 195 (8): 1003–12. PMID 11956291.
Sharma S, Grandvaux N, Mamane Y, et al. (2002). "Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells.". J. Immunol. 169 (6): 3120–30. PMID 12218129.
Escalante CR, Shen L, Escalante MC, et al. (2003). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex.". J. Struct. Biol. 139 (1): 55–9. PMID 12372320.
Hu CM, Jang SY, Fanzo JC, Pernis AB (2003). "Modulation of T cell cytokine production by interferon regulatory factor-4.". J. Biol. Chem. 277 (51): 49238–46. doi:10.1074/jbc.M205895200. PMID 12374808.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fanzo JC, Hu CM, Jang SY, Pernis AB (2003). "Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4).". J. Exp. Med. 197 (3): 303–14. PMID 12566414.
O'Reilly D, Quinn CM, El-Shanawany T, et al. (2003). "Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner.". J. Biol. Chem. 278 (24): 21909–19. doi:10.1074/jbc.M212150200. PMID 12676954.
Sundram U, Harvell JD, Rouse RV, Natkunam Y (2004). "Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA.". Mod. Pathol. 16 (8): 802–10. doi:10.1097/01.MP.0000081726.49886.CF. PMID 12920225.

[edit] External links

MeSH IRF4+protein,+human

This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.

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v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD

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IRF4

From Wikipedia, the free encyclopedia

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[edit] See also

[edit] References

[edit] Further reading

[edit] External links

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