ELK4

From Wikipedia, the free encyclopedia

ELK4, ETS-domain protein (SRF accessory protein 1)

PDB rendering based on 1bc7.

Available structures: 1bc7, 1bc8, 1hbx, 1k6o

Identifiers

Symbol(s)

ELK4; SAP1

External IDs

OMIM: 600246 MGI: 102853 HomoloGene: 1492

Gene ontology
Molecular Function:	• transcription factor activity • transcription cofactor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001973 (mRNA)
NP_001964 (protein)

NM_007923 (mRNA)
NP_031949 (protein)

Location

Chr 1: 203.83 - 203.87 Mb

Chr 1: 133.84 - 133.86 Mb

Pubmed search

[1]

[2]

ELK4, ETS-domain protein (SRF accessory protein 1), also known as ELK4, is a human gene.^[1]

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1).

[edit] Further reading

Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family.". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. PMID 9570133.
Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway.". Trends Biochem. Sci. 23 (6): 213–6. PMID 9644975.
Dalton S, Treisman R (1992). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.". Cell 68 (3): 597–612. PMID 1339307.
Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).". EMBO J. 14 (11): 2589–601. PMID 7540136.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Shipley J, Sheer D, Dalton S, et al. (1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively.". Genomics 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.
Dalton S, Treisman R (1994). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.". Cell 76 (2): 411. PMID 8293474.
Giovane A, Sobieszczuk P, Mignon C, et al. (1996). "Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes.". Genomics 29 (3): 769–72. doi:10.1006/geno.1995.9938. PMID 8575773.
Janknecht R, Hunter T (1997). "Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase.". J. Biol. Chem. 272 (7): 4219–24. PMID 9020136.
Janknecht R, Hunter T (1997). "Convergence of MAP kinase pathways on the ternary complex factor Sap-1a.". EMBO J. 16 (7): 1620–7. doi:10.1093/emboj/16.7.1620. PMID 9130707.
Stein B, Yang MX, Young DB, et al. (1997). "p38-2, a novel mitogen-activated protein kinase with distinct properties.". J. Biol. Chem. 272 (31): 19509–17. PMID 9235954.
Mo Y, Vaessen B, Johnston K, Marmorstein R (1998). "Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.". Mol. Cell 2 (2): 201–12. PMID 9734357.
Yates PR, Atherton GT, Deed RW, et al. (1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors.". EMBO J. 18 (4): 968–76. doi:10.1093/emboj/18.4.968. PMID 10022839.
Kamakura S, Moriguchi T, Nishida E (1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus.". J. Biol. Chem. 274 (37): 26563–71. PMID 10473620.
Chai Y, Chipitsyna G, Cui J, et al. (2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells.". Oncogene 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879.
Hassler M, Richmond TJ (2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMID 11406578.
Mo Y, Ho W, Johnston K, Marmorstein R (2002). "Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.". J. Mol. Biol. 314 (3): 495–506. doi:10.1006/jmbi.2001.5138. PMID 11846562.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.

[edit] External links

MeSH ELK4+protein,+human

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD

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ELK4

From Wikipedia, the free encyclopedia

[edit] References

[edit] Further reading

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