ERG (gene)

From Wikipedia, the free encyclopedia

V-ets erythroblastosis virus E26 oncogene homolog (avian)

PDB rendering based on 1fli.

Available structures: 1fli, 1sxe

Identifiers

Symbol(s)

ERG; erg-3; p55

External IDs

OMIM: 165080 MGI: 95415 HomoloGene: 15848

Gene ontology
Molecular Function:	• transcription factor activity • signal transducer activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • protein amino acid phosphorylation • signal transduction • multicellular organismal development • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004449 (mRNA)
NP_004440 (protein)

XM_001004957 (mRNA)
XP_001004957 (protein)

Location

Chr 21: 38.68 - 38.96 Mb

Chr 16: 95.47 - 95.52 Mb

Pubmed search

[1]

[2]

V-ets erythroblastosis virus E26 oncogene homolog (avian), also known as ERG, is a human gene.^[1]

[edit] References

^ Entrez Gene: ERG v-ets erythroblastosis virus E26 oncogene homolog (avian).

[edit] Further reading

Rao VN, Modi WS, Drabkin HD, et al. (1990). "The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia.". Oncogene 3 (5): 497–500. PMID 3274086.
Rao VN, Papas TS, Reddy ES (1987). "erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation.". Science 237 (4815): 635–9. PMID 3299708.
Reddy ES, Rao VN, Papas TS (1987). "The erg gene: a human gene related to the ets oncogene.". Proc. Natl. Acad. Sci. U.S.A. 84 (17): 6131–5. PMID 3476934.
Giovannini M, Biegel JA, Serra M, et al. (1994). "EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.". J. Clin. Invest. 94 (2): 489–96. PMID 8040301.
Dunn T, Praissman L, Hagag N, Viola MV (1994). "ERG gene is translocated in an Ewing's sarcoma cell line.". Cancer Genet. Cytogenet. 76 (1): 19–22. PMID 8076344.
Ichikawa H, Shimizu K, Hayashi Y, Ohki M (1994). "An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.". Cancer Res. 54 (11): 2865–8. PMID 8187069.
Prasad DD, Rao VN, Lee L, Reddy ES (1994). "Differentially spliced erg-3 product functions as a transcriptional activator.". Oncogene 9 (2): 669–73. PMID 8290279.
Murakami K, Mavrothalassitis G, Bhat NK, et al. (1993). "Human ERG-2 protein is a phosphorylated DNA-binding protein--a distinct member of the ets family.". Oncogene 8 (6): 1559–66. PMID 8502479.
Duterque-Coquillaud M, Niel C, Plaza S, Stehelin D (1993). "New human erg isoforms generated by alternative splicing are transcriptional activators.". Oncogene 8 (7): 1865–73. PMID 8510931.
Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.". J. Biol. Chem. 272 (42): 26188–95. PMID 9334186.
Carrère S, Verger A, Flourens A, et al. (1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.". Oncogene 16 (25): 3261–8. doi:10.1038/sj.onc.1201868. PMID 9681824.
McLaughlin F, Ludbrook VJ, Kola I, et al. (2000). "Characterisation of the tumour necrosis factor (TNF)-(alpha) response elements in the human ICAM-2 promoter.". J. Cell. Sci. 112 ( Pt 24): 4695–703. PMID 10574717.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Mastrangelo T, Modena P, Tornielli S, et al. (2000). "A novel zinc finger gene is fused to EWS in small round cell tumor.". Oncogene 19 (33): 3799–804. doi:10.1038/sj.onc.1203762. PMID 10949935.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Verger A, Buisine E, Carrère S, et al. (2001). "Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation.". J. Biol. Chem. 276 (20): 17181–9. doi:10.1074/jbc.M010208200. PMID 11278640.
Yang L, Xia L, Wu DY, et al. (2002). "Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.". Oncogene 21 (1): 148–52. doi:10.1038/sj.onc.1204998. PMID 11791185.
Mackereth CD, Schärpf M, Gentile LN, McIntosh LP (2003). "Chemical shift and secondary structure conservation of the PNT/SAM domains from the ets family of transcription factors.". J. Biomol. NMR 24 (1): 71–2. PMID 12449421.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsui Y, Chansky HA, Barahmand-Pour F, et al. (2003). "COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG.". J. Biol. Chem. 278 (13): 11369–75. doi:10.1074/jbc.M300164200. PMID 12554743.

[edit] External links

MeSH ERG+protein,+human

This article on a gene on chromosome 21 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD

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ERG (gene)

From Wikipedia, the free encyclopedia

[edit] References

[edit] Further reading

[edit] External links

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