Neuron-derived orphan receptor 1

From Wikipedia, the free encyclopedia

Nuclear receptor subfamily 4, group A, member 3

PDB rendering based on 1cit.

Available structures: 1cit

Identifiers

Symbol(s)

NR4A3; CHN; TEC; CSMF; MINOR; NOR1

External IDs

OMIM: 600542 MGI: 1352457 HomoloGene: 5074

Gene ontology
Molecular Function:	• transcription factor activity • steroid hormone receptor activity • thyroid hormone receptor activity • binding • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• mesoderm formation • transcription • regulation of transcription, DNA-dependent • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006981 (mRNA)
NP_008912 (protein)

NM_015743 (mRNA)
NP_056558 (protein)

Location

Chr 9: 101.62 - 101.67 Mb

Chr 4: 48.07 - 48.11 Mb

Pubmed search

[1]

[2]

The Neuron-derived orphan receptor 1 (NOR1) protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR4A3 gene (nuclear receptor subfamily 4, group A, member 3).^[1]

NOR1 plays a central regulatory role in cell proliferation, differentiation, metabolism^[2] ^[3] and apoptosis^[4]

1 See also
2 References
3 External links
4 Further reading

[edit] See also

NUR nuclear receptor family

[edit] References

^ Hedvat CV, Irving SG (1995). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Mol. Endocrinol. 9 (12): 1692–700. doi:10.1210/me.9.12.1692. PMID 8614405.
^ Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967.
^ Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853-65. PMID 18325999.
^ Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D (2006). "The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation". J. Biol. Chem. 281 (44): 33467–76. doi:10.1074/jbc.M603436200. PMID 16945922.

[edit] External links

MeSH NR4A3+protein,+human

[edit] Further reading

Ohkura N, Hijikuro M, Yamamoto A, Miki K (1995). "Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells.". Biochem. Biophys. Res. Commun. 205 (3): 1959–65. doi:10.1006/bbrc.1994.2900. PMID 7811288.
Clark J, Benjamin H, Gill S, et al. (1996). "Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma.". Oncogene 12 (2): 229–35. PMID 8570200.
Hedvat CV, Irving SG (1996). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor.". Mol. Endocrinol. 9 (12): 1692–700. PMID 8614405.
Labelle Y, Zucman J, Stenman G, et al. (1996). "Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation.". Hum. Mol. Genet. 4 (12): 2219–26. PMID 8634690.
Ohkura N, Ito M, Tsukada T, et al. (1996). "Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family.". Biochim. Biophys. Acta 1308 (3): 205–14. PMID 8809112.
Ohkura N, Ito M, Tsukada T, et al. (1998). "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA.". Gene 211 (1): 79–85. PMID 9573341.
Labelle Y, Bussières J, Courjal F, Goldring MB (1999). "The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator.". Oncogene 18 (21): 3303–8. doi:10.1038/sj.onc.1202675. PMID 10359536.
Panagopoulos I, Mencinger M, Dietrich CU, et al. (2000). "Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).". Oncogene 18 (52): 7594–8. doi:10.1038/sj.onc.1203155. PMID 10602519.
Sjögren H, Wedell B, Meis-Kindblom JM, et al. (2001). "Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21).". Cancer Res. 60 (24): 6832–5. PMID 11156374.
Ohkura N, Ohkubo T, Maruyama K, et al. (2001). "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3.". Dev. Neurosci. 23 (1): 17–24. PMID 11173923.
Laflamme C, Filion C, Bridge JA, et al. (2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas.". Cancer Res. 63 (2): 449–54. PMID 12543801.
Liu D, Jia H, Holmes DI, et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.". Arterioscler. Thromb. Vasc. Biol. 23 (11): 2002–7. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795.
Rius J, Martínez-González J, Crespo J, Badimon L (2004). "Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB.". Arterioscler. Thromb. Vasc. Biol. 24 (4): 697–702. doi:10.1161/01.ATV.0000121570.00515.dc. PMID 14962944.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Hisaoka M, Okamoto S, Yokoyama K, Hashimoto H (2004). "Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes.". Cancer Genet. Cytogenet. 152 (2): 101–7. doi:10.1016/j.cancergencyto.2003.11.011. PMID 15262426.
Laflamme C, Filion C, Labelle Y (2005). "Functional characterization of SIX3 homeodomain mutations in holoprosencephaly: interaction with the nuclear receptor NR4A3/NOR1.". Hum. Mutat. 24 (6): 502–8. doi:10.1002/humu.20102. PMID 15523651.
Rius J, Martínez-González J, Crespo J, Badimon L (2006). "NOR-1 is involved in VEGF-induced endothelial cell growth.". Atherosclerosis 184 (2): 276–82. doi:10.1016/j.atherosclerosis.2005.04.008. PMID 15949808.
Pei L, Castrillo A, Chen M, et al. (2005). "Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli.". J. Biol. Chem. 280 (32): 29256–62. doi:10.1074/jbc.M502606200. PMID 15964844.
Bonta PI, van Tiel CM, Vos M, et al. (2006). "Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses.". Arterioscler. Thromb. Vasc. Biol. 26 (10): 2288–94. doi:10.1161/01.ATV.0000238346.84458.5d. PMID 16873729.
Nomiyama T, Nakamachi T, Gizard F, et al. (2006). "The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation.". J. Biol. Chem. 281 (44): 33467–76. doi:10.1074/jbc.M603436200. PMID 16945922.
Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967.
Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853-65. PMID 18325999.

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v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD

Categories: Genes on chromosome 9 | Human proteins | Chromosome 9 gene stubs | Intracellular receptors | Transcription factors

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Neuron-derived orphan receptor 1

From Wikipedia, the free encyclopedia

Contents

[edit] See also

[edit] References

[edit] External links

[edit] Further reading

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