NFYB
From Wikipedia, the free encyclopedia
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Nuclear transcription factor Y, beta
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| PDB rendering based on 1n1j. | ||||||||||||||
| Available structures: 1n1j | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | NFYB; CBF-A; CBF-B; HAP3; NF-YB | |||||||||||||
| External IDs | OMIM: 189904 MGI: 97317 HomoloGene: 38149 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 4801 | 18045 | ||||||||||||
| Ensembl | ENSG00000120837 | ENSMUSG00000020248 | ||||||||||||
| Uniprot | P25208 | Q8C590 | ||||||||||||
| Refseq | NM_006166 (mRNA) NP_006157 (protein) |
NM_010914 (mRNA) NP_035044 (protein) |
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| Location | Chr 12: 103.03 - 103.06 Mb | Chr 10: 82.18 - 82.19 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Nuclear transcription factor Y, beta, also known as NFYB, is a human gene.
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.[1]
[edit] References
[edit] Further reading
- Lloberas J, Soler C, Celada A (1998). "Repression mechanisms of the I-A beta gene of the major histocompatibility complex.". Immunobiology 198 (1-3): 249–63. PMID 9442396.
- Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y.". Gene 239 (1): 15–27. PMID 10571030.
- Li XY, Mantovani R, Hooft van Huijsduijnen R, et al. (1992). "Evolutionary variation of the CCAAT-binding transcription factor NF-Y.". Nucleic Acids Res. 20 (5): 1087–91. PMID 1549471.
- Li XY, Hooft van Huijsduijnen R, Mantovani R, et al. (1992). "Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.". J. Biol. Chem. 267 (13): 8984–90. PMID 1577736.
- Li XY, Mattei MG, Zaleska-Rutczynska Z, et al. (1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes.". Genomics 11 (3): 630–4. PMID 1774067.
- Lloberas J, Maki RA, Celada A (1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins.". Mol. Cell. Biol. 15 (9): 5092–9. PMID 7651426.
- Chang ZF, Liu CJ (1994). "Human thymidine kinase CCAAT-binding protein is NF-Y, whose A subunit expression is serum-dependent in human IMR-90 diploid fibroblasts.". J. Biol. Chem. 269 (27): 17893–8. PMID 8027044.
- Mantovani R, Li XY, Pessara U, et al. (1994). "Dominant negative analogs of NF-YA.". J. Biol. Chem. 269 (32): 20340–6. PMID 8051128.
- Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y.". Mol. Cell. Biol. 17 (3): 1236–43. PMID 9032250.
- Bellorini M, Lee DK, Dantonel JC, et al. (1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues.". Nucleic Acids Res. 25 (11): 2174–81. PMID 9153318.
- Currie RA (1998). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y).". J. Biol. Chem. 272 (49): 30880–8. PMID 9388234.
- Currie RA (1998). "NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF.". J. Biol. Chem. 273 (3): 1430–4. PMID 9430679.
- Currie RA (1998). "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development.". J. Biol. Chem. 273 (29): 18220–9. PMID 9660784.
- Bemark M, Olsson H, Heinegård D, Leanderson T (1998). "Purification and characterization of a protein binding to the SP6 kappa promoter. A potential role for CArG-box binding factor-A in kappa transcription.". J. Biol. Chem. 273 (30): 18881–90. PMID 9668064.
- Faniello MC, Bevilacqua MA, Condorelli G, et al. (1999). "The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300.". J. Biol. Chem. 274 (12): 7623–6. PMID 10075648.
- Hake SB, Masternak K, Kammerbauer C, et al. (2000). "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.". Mol. Cell. Biol. 20 (20): 7716–25. PMID 11003667.
- Liang F, Schaufele F, Gardner DG (2001). "Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription.". J. Biol. Chem. 276 (2): 1516–22. doi:. PMID 11022037.
- Izumi H, Molander C, Penn LZ, et al. (2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor.". J. Cell. Sci. 114 (Pt 8): 1533–44. PMID 11282029.
[edit] External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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