MNX1

From Wikipedia, the free encyclopedia

Homeobox HB9

Identifiers

MNX1;HLXB9; HB9; HOXHB9; SCRA1

External IDs

OMIM: 142994 MGI: 109160 HomoloGene: 21137

Gene ontology
Molecular Function:	• transcription factor activity • RNA polymerase II transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription from RNA polymerase II promoter • humoral immune response • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005515 (mRNA)
NP_005506 (protein)

NM_019944 (mRNA)
NP_064328 (protein)

Location

Chr 7: 156.49 - 156.5 Mb

Chr 5: 29.8 - 29.81 Mb

Pubmed search

[1]

[2]

Motor neuron and pancreas homeobox 1 (MNX1) also known as Homeobox HB9 (HLXB9), is a human gene.^[1]

[edit] References

^ Entrez Gene: HLXB9 homeobox HB9.

[edit] Further reading

Catala M (2002). "Genetic control of caudal development.". Clin. Genet. 61 (2): 89–96. PMID 11940082.
Deguchi Y, Kehrl JH (1991). "Nucleotide sequence of a novel diverged human homeobox gene encodes a DNA binding protein.". Nucleic Acids Res. 19 (13): 3742. PMID 1677181.
Deguchi Y, Kehrl JH (1991). "Selective expression of two homeobox genes in CD34-positive cells from human bone marrow.". Blood 78 (2): 323–8. PMID 1712647.
Lynch SA, Bond PM, Copp AJ, et al. (1995). "A gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36.". Nat. Genet. 11 (1): 93–5. doi:10.1038/ng0995-93. PMID 7550324.
Harrison KA, Druey KM, Deguchi Y, et al. (1994). "A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues.". J. Biol. Chem. 269 (31): 19968–75. PMID 7914194.
Ross AJ, Ruiz-Perez V, Wang Y, et al. (1998). "A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis.". Nat. Genet. 20 (4): 358–61. doi:10.1038/3828. PMID 9843207.
Heus HC, Hing A, van Baren MJ, et al. (1999). "A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36.". Genomics 57 (3): 342–51. doi:10.1006/geno.1999.5796. PMID 10329000.
Belloni E, Martucciello G, Verderio D, et al. (2000). "Involvement of the HLXB9 homeobox gene in Currarino syndrome.". Am. J. Hum. Genet. 66 (1): 312–9. PMID 10631160.
Hagan DM, Ross AJ, Strachan T, et al. (2000). "Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene.". Am. J. Hum. Genet. 66 (5): 1504–15. PMID 10749657.
Köchling J, Karbasiyan M, Reis A (2001). "Spectrum of mutations and genotype-phenotype analysis in Currarino syndrome.". Eur. J. Hum. Genet. 9 (8): 599–605. doi:10.1038/sj.ejhg.5200683. PMID 11528505.
Nagel S, Scherr M, Quentmeier H, et al. (2005). "HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3.". Leukemia 19 (5): 841–6. doi:10.1038/sj.leu.2403716. PMID 15772702.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
Hori Y, Gu X, Xie X, Kim SK (2006). "Differentiation of insulin-producing cells from human neural progenitor cells.". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMID 15839736.
Kapranov P, Drenkow J, Cheng J, et al. (2005). "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays.". Genome Res. 15 (7): 987–97. doi:10.1101/gr.3455305. PMID 15998911.
von Bergh AR, van Drunen E, van Wering ER, et al. (2006). "High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9.". Genes Chromosomes Cancer 45 (8): 731–9. doi:10.1002/gcc.20335. PMID 16646086.
Kim IS, Oh SY, Choi SJ, et al. (2007). "Clinical and genetic analysis of HLXB9 gene in Korean patients with Currarino syndrome.". J. Hum. Genet. 52 (8): 698–701. doi:10.1007/s10038-007-0173-y. PMID 17612791.

[edit] External links

MeSH MNX1+protein,+human

This article on a gene on chromosome 7 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD