GATA3

From Wikipedia, the free encyclopedia

GATA binding protein 3

Identifiers

GATA3; HDR; MGC2346; MGC5199; MGC5445

External IDs

OMIM: 131320 MGI: 95663 HomoloGene: 1550

Gene ontology
Molecular Function:	• transcription factor activity • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • defense response • sensory perception of sound • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001002295 (mRNA)
NP_001002295 (protein)

NM_008091 (mRNA)
NP_032117 (protein)

Location

Chr 10: 8.14 - 8.16 Mb

Chr 2: 9.77 - 9.8 Mb

Pubmed search

[1]

[2]

GATA binding protein 3, also known as GATA3, is a human gene.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

GATA transcription factor

[edit] References

^ Entrez Gene: GATA3 GATA binding protein 3.

[edit] Further reading

Naylor MJ, Ormandy CJ (2007). "Gata-3 and mammary cell fate.". Breast Cancer Res. 9 (2): 302. doi:10.1186/bcr1661. PMID 17381824.
Ho IC, Vorhees P, Marin N, et al. (1991). "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.". EMBO J. 10 (5): 1187–92. PMID 1827068.
Marine J, Winoto A (1991). "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7284–8. PMID 1871134.
Ko LJ, Yamamoto M, Leonard MW, et al. (1991). "Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.". Mol. Cell. Biol. 11 (5): 2778–84. PMID 2017177.
Joulin V, Bories D, Eléouet JF, et al. (1991). "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.". EMBO J. 10 (7): 1809–16. PMID 2050118.
Siegel MD, Zhang DH, Ray P, Ray A (1995). "Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements.". J. Biol. Chem. 270 (41): 24548–55. PMID 7592673.
Labastie MC, Bories D, Chabret C, et al. (1994). "Structure and expression of the human GATA3 gene.". Genomics 21 (1): 1–6. doi:10.1006/geno.1994.1217. PMID 8088776.
Ono Y, Fukuhara N, Yoshie O (1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL.". J. Biol. Chem. 272 (7): 4576–81. PMID 9020185.
Ono Y, Fukuhara N, Yoshie O (1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.". Mol. Cell. Biol. 18 (12): 6939–50. PMID 9819382.
Yang GP, Ross DT, Kuang WW, et al. (1999). "Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes.". Nucleic Acids Res. 27 (6): 1517–23. PMID 10037815.
Blumenthal SG, Aichele G, Wirth T, et al. (1999). "Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1.". J. Biol. Chem. 274 (18): 12910–6. PMID 10212281.
Van Esch H, Groenen P, Nesbit MA, et al. (2000). "GATA3 haplo-insufficiency causes human HDR syndrome.". Nature 406 (6794): 419–22. doi:10.1038/35019088. PMID 10935639.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Muroya K, Hasegawa T, Ito Y, et al. (2001). "GATA3 abnormalities and the phenotypic spectrum of HDR syndrome.". J. Med. Genet. 38 (6): 374–80. PMID 11389161.
Crawford SE, Qi C, Misra P, et al. (2002). "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.". J. Biol. Chem. 277 (5): 3585–92. doi:10.1074/jbc.M107995200. PMID 11724781.
Kieffer LJ, Greally JM, Landres I, et al. (2002). "Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3.". J. Immunol. 168 (8): 3915–22. PMID 11937547.
Asnagli H, Afkarian M, Murphy KM (2002). "Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human.". J. Immunol. 168 (9): 4268–71. PMID 11970965.
Steenbergen RD, OudeEngberink VE, Kramer D, et al. (2002). "Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis.". Am. J. Pathol. 160 (6): 1945–51. PMID 12057898.
Höfer T, Nathansen H, Löhning M, et al. (2002). "GATA-3 transcriptional imprinting in Th2 lymphocytes: a mathematical model.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9364–8. doi:10.1073/pnas.142284699. PMID 12087127.
Karunaratne A, Hargrave M, Poh A, Yamada T (2002). "GATA proteins identify a novel ventral interneuron subclass in the developing chick spinal cord.". Dev. Biol. 249 (1): 30–43. PMID 12217316.

[edit] External links

MeSH GATA3+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD