KLF10

From Wikipedia, the free encyclopedia

Kruppel-like factor 10

Identifiers

KLF10; EGRA; TIEG; TIEG1

External IDs

OMIM: 601878 MGI: 1101353 HomoloGene: 4135

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • skeletal development • regulation of transcription, DNA-dependent • transforming growth factor beta receptor signaling pathway • cell-cell signaling • cell proliferation • negative regulation of cell proliferation • bone mineralization • positive regulation of osteoclast differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001032282 (mRNA)
NP_001027453 (protein)

NM_013692 (mRNA)
NP_038720 (protein)

Location

Chr 8: 103.73 - 103.74 Mb

Chr 15: 38.24 - 38.25 Mb

Pubmed search

[1]

[2]

Kruppel-like factor 10, also known as KLF10, is a human gene.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Kruppel-like factors

[edit] References

^ Entrez Gene: KLF10 Kruppel-like factor 10.

[edit] Further reading

Subramaniam M, Harris SA, Oursler MJ, et al. (1996). "Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts.". Nucleic Acids Res. 23 (23): 4907-12. PMID 8532536.
Blok LJ, Grossmann ME, Perry JE, Tindall DJ (1996). "Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation.". Mol. Endocrinol. 9 (11): 1610-20. PMID 8584037.
Tachibana I, Imoto M, Adjei PN, et al. (1997). "Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells.". J. Clin. Invest. 99 (10): 2365-74. PMID 9153278.
Subramaniam M, Hefferan TE, Tau K, et al. (1998). "Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene.". J. Cell. Biochem. 68 (2): 226-36. PMID 9443078.
Fautsch MP, Vrabel A, Subramaniam M, et al. (1998). "TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters.". Genomics 51 (3): 408-16. doi:10.1006/geno.1998.5388. PMID 9721211.
Cook T, Gebelein B, Mesa K, et al. (1998). "Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth.". J. Biol. Chem. 273 (40): 25929-36. PMID 9748269.
Hefferan TE, Reinholz GG, Rickard DJ, et al. (2000). "Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells.". J. Biol. Chem. 275 (27): 20255-9. doi:10.1074/jbc.C000135200. PMID 10816551.
Gunther M, Laithier M, Brison O (2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.". Mol. Cell. Biochem. 210 (1-2): 131-42. PMID 10976766.
Antonello D, Moore PS, Zamboni G, et al. (2002). "Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer.". Cancer Lett. 183 (2): 179-83. PMID 12065093.
Johnsen SA, Subramaniam M, Monroe DG, et al. (2002). "Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue.". J. Biol. Chem. 277 (34): 30754-9. doi:10.1074/jbc.M204812200. PMID 12072443.
Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC (2002). "TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.". Oncogene 21 (37): 5783-90. doi:10.1038/sj.onc.1205681. PMID 12173049.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chrisman HR, Tindall DJ (2003). "Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha.". DNA Cell Biol. 22 (3): 187-99. doi:10.1089/104454903321655819. PMID 12804117.
Noti JD, Johnson AK, Dillon JD (2004). "The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter.". J. Biol. Chem. 279 (26): 26948-58. doi:10.1074/jbc.M310634200. PMID 15087465.
Reinholz MM, An MW, Johnsen SA, et al. (2004). "Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.". Breast Cancer Res. Treat. 86 (1): 75-88. doi:10.1023/B:BREA.0000032926.74216.7d. PMID 15218362.
Johnsen SA, Subramaniam M, Effenberger KE, and Spelsberg TC (2004). "The TGFβ Inducible Early Gene Plays a Central Role in the Anti-Proliferative Response to TGFβ.". Signal Transduction 4: 29-35. doi:10.1002/sita.200400032.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JMA, Turner RT, Oursler MJ, and Spelsberg TC (2005). "TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro.". Mol. Cell. Biol. 25: 1191-1199. doi:10.1128/MCB.25.3.1191-1199.2005. PMID 15657444.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Fueki N, Sagara H, Akimoto K, et al. (2007). "Interleukin-10 regulates transforming growth factor-beta signaling in cultured human bronchial epithelial cells.". Respiration; international review of thoracic diseases 74 (4): 454-9. doi:10.1159/000101057. PMID 17377371.
Jin W, Di G, Li J, et al. (2007). "TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade.". FEBS Lett. 581 (20): 3826-32. doi:10.1016/j.febslet.2007.07.008. PMID 17659279.
Subramaniam M, Hawse JR, Johnsen SA, and Spelsberg TC (2007). "TIEG1: An Important Regulator of Multiple Biological Processes and Disease States.". J. Cell. Biochem. 102 (3): 539-548. doi:10.1002/jcb.21492. PMID 17729309.

[edit] External links

MeSH KLF10+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 8 is a stub. You can help Wikipedia by expanding it.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD