POU4F2

From Wikipedia, the free encyclopedia

POU domain, class 4, transcription factor 2

Identifiers

POU4F2; BRN3.2; BRN3B; Brn-3b

External IDs

OMIM: 113725 MGI: 102524 HomoloGene: 20959

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-dependent • nervous system development • axon guidance • neuron differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004575 (mRNA)
NP_004566 (protein)

NM_138944 (mRNA)
NP_620394 (protein)

Location

Chr 4: 147.78 - 147.78 Mb

Chr 8: 81.33 - 81.33 Mb

Pubmed search

[1]

[2]

POU domain, class 4, transcription factor 2, also known as POU4F2, is a human gene.^[1]

POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM]^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

BRN-3

[edit] References

^ ^a ^b Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2.

[edit] Further reading

Xiang M, Zhou L, Macke JP, et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.". J. Neurosci. 15 (7 Pt 1): 4762–85. PMID 7623109.
Xiang M, Zhou L, Peng YW, et al. (1993). "Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells.". Neuron 11 (4): 689–701. PMID 7691107.
Bhargava AK, Li Z, Weissman SM (1993). "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 10260–4. PMID 8234287.
Ring CJ, Latchman DS (1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain.". Nucleic Acids Res. 21 (12): 2946. PMID 8332509.
Smith MD, Dawson SJ, Latchman DS (1997). "Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor.". J. Biol. Chem. 272 (2): 1382–8. PMID 8995448.
Budhram-Mahadeo V, Parker M, Latchman DS (1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.". Mol. Cell. Biol. 18 (2): 1029–41. PMID 9448000.
Dennis JH, Budhram-Mahadeo V, Latchman DS (2001). "The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells.". Oncogene 20 (36): 4961–71. doi:10.1038/sj.onc.1204491. PMID 11526481.
de Melo J, Qiu X, Du G, et al. (2003). "Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina.". J. Comp. Neurol. 461 (2): 187–204. doi:10.1002/cne.10674. PMID 12724837.
Samady L, Dennis J, Budhram-Mahadeo V, Latchman DS (2004). "Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor.". Cancer Biol. Ther. 3 (3): 317–23. PMID 14726699.
Irshad S, Pedley RB, Anderson J, et al. (2004). "The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo.". J. Biol. Chem. 279 (20): 21617–27. doi:10.1074/jbc.M312506200. PMID 14970234.
Lee SA, Ndisang D, Patel C, et al. (2005). "Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.". Cancer Res. 65 (8): 3072–80. doi:10.1158/0008-5472.CAN-04-2865. PMID 15833836.
Weishaupt JH, Klöcker N, Bähr M (2005). "Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells.". J. Mol. Neurosci. 26 (1): 17–25. PMID 15968082.
Samady L, Faulkes DJ, Budhram-Mahadeo V, et al. (2006). "The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells.". Int. J. Cancer 118 (4): 869–78. doi:10.1002/ijc.21435. PMID 16152597.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes.". Physiol. Genomics 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
Calissano M, Diss JK, Latchman DS (2007). "Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells.". FEBS Lett. 581 (13): 2490–6. doi:10.1016/j.febslet.2007.04.066. PMID 17490655.

[edit] External links

MeSH POU4F2+protein,+human

This article on a gene on chromosome 4 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD