FOXO3A

From Wikipedia, the free encyclopedia

Forkhead box O3A

Identifiers

FOXO3A; AF6q21; DKFZp781A0677; FKHRL1; FKHRL1P2; MGC12739; MGC31925

External IDs

OMIM: 602681 MGI: 1890081 HomoloGene: 31039

Gene ontology
Molecular Function:	• transcription factor activity • transcription activator activity • protein kinase binding • sequence-specific DNA binding
Cellular Component:	• membrane fraction • nucleus • cytoplasm
Biological Process:	• ovulation (sensu Mammalia) • initiation of primordial ovarian follicle growth • antral ovarian follicle growth • oocyte maturation • transcription • regulation of transcription, DNA-dependent • apoptosis • induction of apoptosis • response to DNA damage stimulus • glucose homeostasis • positive regulation of erythrocyte differentiation • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001455 (mRNA)
NP_001446 (protein)

XM_001000298 (mRNA)
XP_001000298 (protein)

Location

Chr 6: 108.99 - 109.11 Mb

Chr 10: 41.87 - 41.97 Mb

Pubmed search

[1]

[2]

Forkhead box O3A, also known as FOXO3A, is a human gene.

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death, such as Bim and Puma. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

FOX proteins

[edit] References

^ Entrez Gene: FOXO3A forkhead box O3A.

[edit] Further reading

Stahl M, et al. (2002). "The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2.". J. Immunol 168: 5024–5031. PMID 11994454.
Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
Hillion J, Le Coniat M, Jonveaux P, et al. (1997). "AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily.". Blood 90 (9): 3714–9. PMID 9345057.
Anderson MJ, Viars CS, Czekay S, et al. (1998). "Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.". Genomics 47 (2): 187–99. doi:10.1006/geno.1997.5122. PMID 9479491.
DaSilva L, Kirken RA, Taub DD, et al. (1998). "Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.". Gene 221 (1): 135–42. PMID 9852958.
Brunet A, Bonni A, Zigmond MJ, et al. (1999). "Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.". Cell 96 (6): 857–68. PMID 10102273.
Medema RH, Kops GJ, Bos JL, Burgering BM (2000). "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.". Nature 404 (6779): 782–7. doi:10.1038/35008115. PMID 10783894.
Brunet A, Park J, Tran H, et al. (2001). "Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).". Mol. Cell. Biol. 21 (3): 952–65. doi:10.1128/MCB.21.3.952-965.2001. PMID 11154281.
Schuur ER, Loktev AV, Sharma M, et al. (2001). "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family.". J. Biol. Chem. 276 (36): 33554–60. doi:10.1074/jbc.M105555200. PMID 11435445.
Kops GJ, Medema RH, Glassford J, et al. (2002). "Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.". Mol. Cell. Biol. 22 (7): 2025–36. PMID 11884591.
Mahmud DL, G-Amlak M, Deb DK, et al. (2002). "Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells.". Oncogene 21 (10): 1556–62. doi:10.1038/sj.onc.1205230. PMID 11896584.
Nadal A, Marrero PF, Haro D (2002). "Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1.". Biochem. J. 366 (Pt 1): 289–97. doi:10.1042/BJ20020598. PMID 12027802.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. PMID 12107410.
Modur V, Nagarajan R, Evers BM, Milbrandt J (2003). "FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer.". J. Biol. Chem. 277 (49): 47928–37. doi:10.1074/jbc.M207509200. PMID 12351634.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Charvet C, Alberti I, Luciano F, et al. (2003). "Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases.". Oncogene 22 (29): 4557–68. doi:10.1038/sj.onc.1206778. PMID 12881712.
Crossley LJ (2003). "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1.". J. Leukoc. Biol. 74 (4): 583–92. doi:10.1189/jlb.0103020. PMID 12960271.
Sunters A, Fernández de Mattos S, Stahl M, et al. (2004). "FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.". J. Biol. Chem. 278 (50): 49795–805. doi:10.1074/jbc.M309523200. PMID 14527951.
Skurk C, Maatz H, Kim HS, et al. (2004). "The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP.". J. Biol. Chem. 279 (2): 1513–25. doi:10.1074/jbc.M304736200. PMID 14551207.
Dansen TB, Kops GJ, Denis S, et al. (2004). "Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a.". J. Lipid Res. 45 (1): 81–8. doi:10.1194/jlr.M300111-JLR200. PMID 14563822.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.

[edit] External links

MeSH FOXO3A+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD