Estrogen receptor alpha

From Wikipedia, the free encyclopedia

Estrogen receptor 1

PDB rendering based on 1a52.

Available structures: 1a52, 1ere, 1err, 1g50, 1gwq, 1gwr, 1hcp, 1hcq, 1l2i, 1pcg, 1qkt, 1qku, 1r5k, 1sj0, 1uom, 1x7e, 1x7r, 1xp1, 1xp6, 1xp9, 1xpc, 1xqc, 1yim, 1yin, 1zky, 2ayr, 2b1v, 2b1z, 2b23, 2bj4, 2fai, 2g44, 2g5o, 2i0j, 2jf9, 2jfa, 2ouz, 2p15, 3erd, 3ert

Identifiers

Symbol(s)

ESR1; ER; DKFZp686N23123; ESR; ESRA; Era; NR3A1

External IDs

OMIM: 133430 MGI: 1352467 HomoloGene: 47906

Gene ontology
Molecular Function:	• DNA binding • transcription factor activity • steroid hormone receptor activity • receptor activity • steroid binding • protein binding • zinc ion binding • lipid binding • nitric-oxide synthase regulator activity • estrogen receptor activity • sequence-specific DNA binding • metal ion binding
Cellular Component:	• nucleus • cytoplasm • membrane • chromatin remodeling complex
Biological Process:	• regulation of transcription, DNA-dependent • signal transduction • cell growth • estrogen receptor signaling pathway • negative regulation of mitosis

Orthologs

Human

Mouse

Refseq

NM_000125 (mRNA)
NP_000116 (protein)

XM_985634 (mRNA)
XP_990728 (protein)

Location

Chr 6: 152.17 - 152.47 Mb

Chr 10: 5.34 - 5.73 Mb

Pubmed search

[1]

[2]

Estrogen receptor alpha (ER-alpha), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is a nuclear receptor which is activated by the sex hormone estrogen. ER-alpha is encoded by the human gene ESR1 (EStrogen Receptor 1).^[1]

The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: ESR1 estrogen receptor 1.

[edit] Further reading

McDonnell DP, Norris JD (2002). "Connections and regulation of the human estrogen receptor.". Science 296 (5573): 1642–4. doi:10.1126/science.1071884. PMID 12040178.
Simoncini T, Fornari L, Mannella P, et al. (2003). "Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system. Interaction of estrogen receptor alpha with phosphatidylinositol 3-OH kinase.". Steroids 67 (12): 935–9. PMID 12398989.
Lannigan DA (2003). "Estrogen receptor phosphorylation.". Steroids 68 (1): 1–9. PMID 12475718.
Herrington DM (2003). "Role of estrogen receptor-alpha in pharmacogenetics of estrogen action.". Curr. Opin. Lipidol. 14 (2): 145–50. doi:10.1097/01.mol.0000064045.68936.23. PMID 12642782.
Tanaka Y, Sasaki M, Kaneuchi M, et al. (2004). "Estrogen receptor alpha polymorphisms and renal cell carcinoma--a possible risk.". Mol. Cell. Endocrinol. 202 (1-2): 109–16. PMID 12770739.
Ali S, Coombes RC (2004). "Estrogen receptor alpha in human breast cancer: occurrence and significance.". Journal of mammary gland biology and neoplasia 5 (3): 271–81. PMID 14973389.
Olsson H (2004). "Estrogen receptor content in malignant breast tumors in men--a review.". Journal of mammary gland biology and neoplasia 5 (3): 283–7. PMID 14973390.
Surmacz E, Bartucci M (2005). "Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer.". J. Exp. Clin. Cancer Res. 23 (3): 385–94. PMID 15595626.
Evinger AJ, Levin ER (2005). "Requirements for estrogen receptor alpha membrane localization and function.". Steroids 70 (5-7): 361–3. doi:10.1016/j.steroids.2005.02.015. PMID 15862818.
Wang CL, Tang XY, Chen WQ, et al. (2007). "Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis.". Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 18 (3): 295–305. doi:10.1007/s00198-006-0239-2. PMID 17089081.
Keaveney M, Klug J, Gannon F (1992). "Sequence analysis of the 5' flanking region of the human estrogen receptor gene.". DNA Seq. 2 (6): 347–58. PMID 1476547.
Piva R, Gambari R, Zorzato F, et al. (1992). "Analysis of upstream sequences of the human estrogen receptor gene.". Biochem. Biophys. Res. Commun. 183 (3): 996–1002. PMID 1567414.
Reese JC, Katzenellenbogen BS (1992). "Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation.". J. Biol. Chem. 267 (14): 9868–73. PMID 1577818.
Dotzlaw H, Alkhalaf M, Murphy LC (1992). "Characterization of estrogen receptor variant mRNAs from human breast cancers.". Mol. Endocrinol. 6 (5): 773–85. PMID 1603086.
Keaveney M, Klug J, Dawson MT, et al. (1991). "Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene.". J. Mol. Endocrinol. 6 (1): 111–5. PMID 2015052.
Reese JC, Katzenellenbogen BS (1991). "Mutagenesis of cysteines in the hormone binding domain of the human estrogen receptor. Alterations in binding and transcriptional activation by covalently and reversibly attaching ligands.". J. Biol. Chem. 266 (17): 10880–7. PMID 2040605.
Schwabe JW, Neuhaus D, Rhodes D (1991). "Solution structure of the DNA-binding domain of the oestrogen receptor.". Nature 348 (6300): 458–61. doi:10.1038/348458a0. PMID 2247153.
Tora L, Mullick A, Metzger D, et al. (1989). "The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.". EMBO J. 8 (7): 1981–6. PMID 2792078.
Ponglikitmongkol M, Green S, Chambon P (1989). "Genomic organization of the human oestrogen receptor gene.". EMBO J. 7 (11): 3385–8. PMID 3145193.
Greene GL, Gilna P, Waterfield M, et al. (1986). "Sequence and expression of human estrogen receptor complementary DNA.". Science 231 (4742): 1150–4. PMID 3753802.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD

Categories: Genes on chromosome 6 | Human proteins | Chromosome 6 gene stubs | Intracellular receptors | Transcription factors

See also ebooksgratis.com: no banners, no cookies, totally FREE.

Estrogen receptor alpha

From Wikipedia, the free encyclopedia

[edit] References

[edit] Further reading

Views

Navigation

Interaction

Search