Urotensin-II receptor

From Wikipedia, the free encyclopedia

Urotensin 2 receptor

Identifiers

UTS2R; GPR14; UTR; UTR2

External IDs

OMIM: 600896 MGI: 2183450 HomoloGene: 10345

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • urotensin II receptor activity • receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • circulation

Orthologs

Human

Mouse

Refseq

NM_018949 (mRNA)
NP_061822 (protein)

NM_145440 (mRNA)
NP_663415 (protein)

Location

Chr 17: 77.93 - 77.93 Mb

Chr 11: 120.98 - 120.98 Mb

Pubmed search

[1]

[2]

The urotensin-II receptor (also referred to as the hypocretin receptor) is a G-protein coupled receptor which binds the peptide hormone urotensin-II.^[1]

[edit] References

^ Douglas SA, Dhanak D, Johns DG (2004). "From 'gills to pills': urotensin-II as a regulator of mammalian cardiorenal function". Trends Pharmacol. Sci. 25 (2): 76–85. doi:10.1016/j.tips.2003.12.005. PMID 15102493.

[edit] Further reading

Marchese A, Heiber M, Nguyen T, et al. (1996). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.". Genomics 29 (2): 335–44. PMID 8666380.
Coulouarn Y, Lihrmann I, Jegou S, et al. (1999). "Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord.". Proc. Natl. Acad. Sci. U.S.A. 95 (26): 15803–8. PMID 9861051.
Ames RS, Sarau HM, Chambers JK, et al. (1999). "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.". Nature 401 (6750): 282–6. doi:10.1038/45809. PMID 10499587.
Liu Q, Pong SS, Zeng Z, et al. (2000). "Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14.". Biochem. Biophys. Res. Commun. 266 (1): 174–8. doi:10.1006/bbrc.1999.1796. PMID 10581185.
Protopopov A, Kashuba V, Podowski R, et al. (2000). "Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization.". Cytogenet. Cell Genet. 88 (3-4): 312–3. PMID 10828617.
Maguire JJ, Kuc RE, Davenport AP (2001). "Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1.". Br. J. Pharmacol. 131 (3): 441–6. doi:10.1038/sj.bjp.0703601. PMID 11015293.
Sugo T, Murakami Y, Shimomura Y, et al. (2003). "Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain.". Biochem. Biophys. Res. Commun. 310 (3): 860–8. PMID 14550283.
Birker-Robaczewska M, Boukhadra C, Studer R, et al. (2004). "The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma.". J. Recept. Signal Transduct. Res. 23 (4): 289–305. PMID 14753294.
Bousette N, Patel L, Douglas SA, et al. (2004). "Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta.". Atherosclerosis 176 (1): 117–23. doi:10.1016/j.atherosclerosis.2004.03.023. PMID 15306183.
Suzuki S, Wenyi Z, Hirai M, et al. (2005). "Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese.". Peptides 25 (10): 1803–8. doi:10.1016/j.peptides.2004.03.030. PMID 15476949.
Qi JS, Minor LK, Smith C, et al. (2005). "Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors.". Peptides 26 (4): 683–90. doi:10.1016/j.peptides.2004.11.018. PMID 15752584.
Lehner U, Velić A, Schroter R, et al. (2007). "Ligands and signaling of the G-protein-coupled receptor GPR14, expressed in human kidney cells.". Cell. Physiol. Biochem. 20 (1-4): 181–92. doi:10.1159/000104165. PMID 17595527.
Segain JP, Rolli-Derkinderen M, Gervois N, et al. (2007). "Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.". J. Immunol. 179 (2): 901–9. PMID 17617581.

[edit] External links

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v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened