Neuropeptide Y receptor Y5

From Wikipedia, the free encyclopedia

Identifiers

External IDs

OMIM: 602001 MGI: 108082 HomoloGene: 21241

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • peptide YY receptor activity • pancreatic polypeptide receptor activity • receptor activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006174 (mRNA)
NP_006165 (protein)

NM_016708 (mRNA)
NP_057917 (protein)

Location

Chr 4: 164.48 - 164.49 Mb

Chr 8: 69.61 - 69.62 Mb

Pubmed search

[1]

[2]

Neuropeptide Y receptor Y5, also known as NPY5R, is a human gene.^[1]

[edit] See also

Neuropeptide Y receptor

[edit] References

^ Entrez Gene: NPY5R neuropeptide Y receptor Y5.

[edit] Further reading

Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. PMID 12007534.
Gerald C, Walker MW, Criscione L, et al. (1996). "A receptor subtype involved in neuropeptide-Y-induced food intake.". Nature 382 (6587): 168–71. doi:10.1038/382168a0. PMID 8700207.
Hu Y, Bloomquist BT, Cornfield LJ, et al. (1996). "Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.". J. Biol. Chem. 271 (42): 26315–9. PMID 8824284.
Herzog H, Darby K, Ball H, et al. (1997). "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation.". Genomics 41 (3): 315–9. doi:10.1006/geno.1997.4684. PMID 9169127.
Lutz CM, Richards JE, Scott KL, et al. (1998). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.". Genomics 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
Nichol KA, Morey A, Couzens MH, et al. (1999). "Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control.". J. Neurosci. 19 (23): 10295–304. PMID 10575027.
Rodriguez M, Audinot V, Dromaint S, et al. (2003). "Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform.". Biochem. J. 369 (Pt 3): 667–73. doi:10.1042/BJ20020739. PMID 12398768.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Berglund MM, Schober DA, Statnick MA, et al. (2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction.". J. Pharmacol. Exp. Ther. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544.
Beauverger P, Rodriguez M, Nicolas JP, et al. (2005). "Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay.". Cell. Signal. 17 (4): 489–96. doi:10.1016/j.cellsig.2004.09.006. PMID 15601626.
Movafagh S, Hobson JP, Spiegel S, et al. (2006). "Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors.". FASEB J. 20 (11): 1924–6. doi:10.1096/fj.05-4770fje. PMID 16891622.
Coletta DK, Schneider J, Stern MP, et al. (2007). "Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans.". Obesity (Silver Spring, Md.) 15 (4): 809–15. PMID 17426313.

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v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened