Somatostatin receptor 2

From Wikipedia, the free encyclopedia

Identifiers

External IDs

OMIM: 182452 MGI: 98328 HomoloGene: 37427

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • receptor activity • somatostatin receptor activity • protein binding • PDZ domain binding
Cellular Component:	• membrane fraction • plasma membrane • integral to plasma membrane
Biological Process:	• signal transduction • G-protein signaling, coupled to cyclic nucleotide second messenger • G-protein signaling, adenylate cyclase inhibiting pathway • neuropeptide signaling pathway • cell-cell signaling • response to nutrient • digestion • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001050 (mRNA)
NP_001041 (protein)

XM_990740 (mRNA)
XP_995834 (protein)

Location

Chr 17: 68.67 - 68.68 Mb

Chr 11: 113.44 - 113.44 Mb

Pubmed search

[1]

[2]

Somatostatin receptor 2, also known as SSTR2, is a human gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Somatostatin receptor

[edit] References

^ Entrez Gene: SSTR2 somatostatin receptor 2.

[edit] Further reading

Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. PMID 1346068.
Reubi JC, Waser B, Schaer JC, Markwalder R (1995). "Somatostatin receptors in human prostate and prostate cancer.". J. Clin. Endocrinol. Metab. 80 (9): 2806–14. PMID 7673428.
Kagimoto S, Yamada Y, Kubota A, et al. (1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.". Biochem. Biophys. Res. Commun. 202 (2): 1188–95. doi:10.1006/bbrc.1994.2054. PMID 7914078.
Fujita T, Yamaji Y, Sato M, et al. (1994). "Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines.". Life Sci. 55 (23): 1797–806. PMID 7968260.
Patel YC, Greenwood M, Kent G, et al. (1993). "Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.". Biochem. Biophys. Res. Commun. 192 (1): 288–94. doi:10.1006/bbrc.1993.1412. PMID 8386508.
Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.". Genomics 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide.". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.". Eur. J. Clin. Invest. 27 (8): 639–44. PMID 9279525.
Lopez F, Estève JP, Buscail L, et al. (1997). "The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling.". J. Biol. Chem. 272 (39): 24448–54. PMID 9305905.
Tsutsumi A, Takano H, Ichikawa K, et al. (1997). "Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells.". Cell. Immunol. 181 (1): 44–9. doi:10.1006/cimm.1997.1193. PMID 9344495.
Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.". Mol. Endocrinol. 13 (1): 82–90. PMID 9892014.
Kumar U, Sasi R, Suresh S, et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.". Diabetes 48 (1): 77–85. PMID 9892225.
Zitzer H, Richter D, Kreienkamp HJ (1999). "Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.". J. Biol. Chem. 274 (26): 18153–6. PMID 10373412.
Zitzer H, Hönck HH, Bächner D, et al. (2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.". J. Biol. Chem. 274 (46): 32997–3001. PMID 10551867.
Petersenn S, Rasch AC, Presch S, et al. (2000). "Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.". Mol. Cell. Endocrinol. 157 (1-2): 75–85. PMID 10619399.
Kreienkamp HJ, Zitzer H, Richter D (2001). "Identification of proteins interacting with the rat somatostatin receptor subtype 2.". J. Physiol. Paris 94 (3-4): 193–8. PMID 11087996.
Ho MK, Yung LY, Chan JS, et al. (2001). "Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C.". Br. J. Pharmacol. 132 (7): 1431–40. doi:10.1038/sj.bjp.0703933. PMID 11264236.
Zatelli MC, Tagliati F, Taylor JE, et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. PMID 11344221.
Talme T, Ivanoff J, Hägglund M, et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.". Clin. Exp. Immunol. 125 (1): 71–9. PMID 11472428.
Klisovic DD, O'Dorisio MS, Katz SE, et al. (2001). "Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study.". Invest. Ophthalmol. Vis. Sci. 42 (10): 2193–201. PMID 11527930.

[edit] External links

v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened