LPHN1
From Wikipedia, the free encyclopedia
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Latrophilin 1
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| Identifiers | ||||||||||||||
| Symbol(s) | LPHN1; CIRL1; CL1; LEC2 | |||||||||||||
| External IDs | MGI: 1929461 HomoloGene: 8951 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 22859 | 330814 | ||||||||||||
| Ensembl | ENSG00000072071 | ENSMUSG00000013033 | ||||||||||||
| Uniprot | O94910 | Q3UYB4 | ||||||||||||
| Refseq | NM_001008701 (mRNA) NP_001008701 (protein) |
NM_181039 (mRNA) NP_851382 (protein) |
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| Location | Chr 19: 14.12 - 14.18 Mb | Chr 8: 86.79 - 86.83 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Latrophilin 1, also known as LPHN1, is a human gene.[1]
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane.[1]
[edit] See also
[edit] References
[edit] Further reading
- Hayflick JS (2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.". J. Recept. Signal Transduct. Res. 20 (2-3): 119-31. PMID 10994649.
- Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.". Annu. Rev. Neurosci. 24: 933-62. doi:. PMID 11520923.
- Ushkaryov YA, Volynski KE, Ashton AC (2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.". Toxicon 43 (5): 527-42. doi:. PMID 15066411.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355-64. PMID 10048485.
- Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.". J. Biol. Chem. 275 (42): 32387-90. doi:. PMID 10964907.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:. PMID 14702039.
- Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763-72. doi:. PMID 15144186.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23-33. doi:. PMID 15203201.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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