Prokineticin receptor 2
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Prokineticin receptor 2
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Identifiers | ||||||||||||||
Symbol(s) | PROKR2; KAL3; PKR2; GPR73L1; GPR73b; GPRg2; dJ680N4.3 | |||||||||||||
External IDs | OMIM: 607123 MGI: 2181363 HomoloGene: 16368 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 128674 | 246313 | ||||||||||||
Ensembl | ENSG00000101292 | ENSMUSG00000050558 | ||||||||||||
Uniprot | Q8NFJ6 | Q6GTF8 | ||||||||||||
Refseq | NM_144773 (mRNA) NP_658986 (protein) |
NM_144944 (mRNA) NP_659193 (protein) |
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Location | Chr 20: 5.23 - 5.24 Mb | Chr 2: 132.06 - 132.08 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Prokineticin receptor 2, also known as PROKR2, is a human gene.[1]
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[1]
[edit] See also
[edit] References
[edit] Further reading
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi: . PMID 11780052.
- Lin DC, Bullock CM, Ehlert FJ, et al. (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.". J. Biol. Chem. 277 (22): 19276-80. doi: . PMID 11886876.
- Soga T, Matsumoto S, Oda T, et al. (2003). "Molecular cloning and characterization of prokineticin receptors.". Biochim. Biophys. Acta 1579 (2-3): 173-9. PMID 12427552.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi: . PMID 12477932.
- Battersby S, Critchley HO, Morgan K, et al. (2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.". J. Clin. Endocrinol. Metab. 89 (5): 2463-9. PMID 15126578.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi: . PMID 15489334.
- Pasquali D, Rossi V, Staibano S, et al. (2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy.". Endocrinology 147 (9): 4245-51. doi: . PMID 16763065.
- Dodé C, Teixeira L, Levilliers J, et al. (2006). "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2.". PLoS Genet. 2 (10): e175. doi: . PMID 17054399.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.