C3a receptor

From Wikipedia, the free encyclopedia

Complement component 3a receptor 1

Identifiers

C3AR1; AZ3B; C3AR; HNFAG09

External IDs

OMIM: 605246 MGI: 1097680 HomoloGene: 2992

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • phosphoinositide phospholipase C activity • receptor activity • complement component C3a receptor activity • C3a anaphylatoxin receptor activity
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• cell motility • chemotaxis • smooth muscle contraction • inflammatory response • cellular defense response • signal transduction • G-protein coupled receptor protein signaling pathway • elevation of cytosolic calcium ion concentration • circulation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004054 (mRNA)
NP_004045 (protein)

NM_009779 (mRNA)
NP_033909 (protein)

Location

Chr 12: 8.1 - 8.11 Mb

Chr 6: 122.81 - 122.82 Mb

Pubmed search

[1]

[2]

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.^[1]^[2]

Although its official name implies it only binds C3a, it also binds C4a.

[edit] References

^ Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochim. Biophys. Acta 1305 (1-2): 39–43. PMID 8605247.
^ Ali H, Panettieri RA (2005). "Anaphylatoxin C3a receptors in asthma". Respir. Res. 6: 19. doi:10.1186/1465-9921-6-19. PMID 15723703.

[edit] Further reading

Sim RB, Laich A (2001). "Serine proteases of the complement system.". Biochem. Soc. Trans. 28 (5): 545–50. PMID 11044372.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Roglic A, Prossnitz ER, Cavanagh SL, et al. (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure.". Biochim. Biophys. Acta 1305 (1-2): 39–43. PMID 8605247.
Ames RS, Li Y, Sarau HM, et al. (1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor.". J. Biol. Chem. 271 (34): 20231–4. PMID 8702752.
Crass T, Raffetseder U, Martin U, et al. (1996). "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells.". Eur. J. Immunol. 26 (8): 1944–50. PMID 8765043.
Ames RS, Nuthulaganti P, Kumar C (1996). "In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins.". FEBS Lett. 395 (2-3): 157–9. PMID 8898085.
Martin U, Bock D, Arseniev L, et al. (1997). "The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes.". J. Exp. Med. 186 (2): 199–207. PMID 9221749.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Hollmann TJ, Haviland DL, Kildsgaard J, et al. (1998). "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene.". Mol. Immunol. 35 (3): 137–48. PMID 9694514.
Lienenklaus S, Ames RS, Tornetta MA, et al. (1998). "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor.". J. Immunol. 161 (5): 2089–93. PMID 9725198.
Davoust N, Jones J, Stahel PF, et al. (1999). "Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells.". Glia 26 (3): 201–11. PMID 10340761.
Settmacher B, Bock D, Saad H, et al. (1999). "Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a.". J. Immunol. 162 (12): 7409–16. PMID 10358194.
Feild JA, Foley JJ, Testa TT, et al. (1999). "Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15.". FEBS Lett. 460 (1): 53–6. PMID 10571060.
Petering H, Köhl J, Weyergraf A, et al. (2000). "Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a.". J. Immunol. 164 (7): 3783–9. PMID 10725738.
Drouin SM, Kildsgaard J, Haviland J, et al. (2001). "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma.". J. Immunol. 166 (3): 2025–32. PMID 11160252.
Ames RS, Lee D, Foley JJ, et al. (2001). "Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.". J. Immunol. 166 (10): 6341–8. PMID 11342658.
Kirchhoff K, Weinmann O, Zwirner J, et al. (2001). "Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin.". Immunology 103 (2): 210–7. PMID 11412308.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Reca R, Mastellos D, Majka M, et al. (2003). "Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1.". Blood 101 (10): 3784–93. doi:10.1182/blood-2002-10-3233. PMID 12511407.

[edit] External links

This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.

v • d • e Proteins: complement system (C, L, A)

Activators	CLA: C3-convertase - C5-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin

Enzymes	C: C1Q/C1R/C1S - C4 (C4a) - C2 - CLA: C3 (C3a, C3b/iC3b) - C5 (C5a) - L: MASP1 - MASP2 - A: Complement factor B - Factor D

Inhibitors	CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H

Complement receptors	CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a)

v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened