EDG6

From Wikipedia, the free encyclopedia

Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6

Identifiers

EDG6; LPC1; S1P4; S1PR4; SLP4

External IDs

OMIM: 603751 MGI: 1333809 HomoloGene: 2799

Gene ontology
Molecular Function:	• lysosphingolipid and lysophosphatidic acid receptor activity • receptor activity • lipid binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• immune response • signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, adenylate cyclase activating pathway • phospholipase C activation • elevation of cytosolic calcium ion concentration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003775 (mRNA)
NP_003766 (protein)

NM_010102 (mRNA)
NP_034232 (protein)

Location

Chr 19: 3.13 - 3.13 Mb

Chr 10: 80.9 - 80.9 Mb

Pubmed search

[1]

[2]

EDG6 (endothelial differentiation gene 1) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₄.^[1]

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Lysophospholipid receptor

[edit] References

^ ^a ^b Entrez Gene: EDG6 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6.

[edit] Further reading

Gräler MH, Bernhardt G, Lipp M (1998). "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue.". Genomics 53 (2): 164–9. doi:10.1006/geno.1998.5491. PMID 9790765.
Yamazaki Y, Kon J, Sato K, et al. (2000). "Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.". Biochem. Biophys. Res. Commun. 268 (2): 583–9. doi:10.1006/bbrc.2000.2162. PMID 10679247.
Van Brocklyn JR, Gräler MH, Bernhardt G, et al. (2000). "Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.". Blood 95 (8): 2624–9. PMID 10753843.
Idzko M, Panther E, Corinti S, et al. (2002). "Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.". FASEB J. 16 (6): 625–7. PMID 11919175.
Kveberg L, Bryceson Y, Inngjerdingen M, et al. (2002). "Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases.". Eur. J. Immunol. 32 (7): 1856–64. doi:10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B. PMID 12115604.
Candelore MR, Wright MJ, Tota LM, et al. (2002). "Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.". Biochem. Biophys. Res. Commun. 297 (3): 600–6. PMID 12270137.
Contos JJ, Ye X, Sah VP, Chun J (2002). "Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene.". FEBS Lett. 531 (1): 99–102. PMID 12401211.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
Gräler MH, Grosse R, Kusch A, et al. (2003). "The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13.". J. Cell. Biochem. 89 (3): 507–19. doi:10.1002/jcb.10537. PMID 12761884.
Kyi CS, Key SJ, Lloyd TW (2003). "Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm.". International journal of oral and maxillofacial surgery 32 (3): 337–8. doi:10.1054/ijom.2003.0364. PMID 12767884.
Holdsworth G, Osborne DA, Pham TT, et al. (2005). "A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.". BMC Biochem. 5: 12. doi:10.1186/1471-2091-5-12. PMID 15298705.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

[edit] External links

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v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened