F2RL2

From Wikipedia, the free encyclopedia

Coagulation factor II (thrombin) receptor-like 2

Identifiers

External IDs

OMIM: 601919 MGI: 1298208 HomoloGene: 36151

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • phosphoinositide phospholipase C activity • receptor activity • thrombin receptor activity
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • blood coagulation • response to wounding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004101 (mRNA)
NP_004092 (protein)

NM_010170 (mRNA)
NP_034300 (protein)

Location

Chr 5: 75.95 - 75.95 Mb

Chr 13: 96.8 - 96.8 Mb

Pubmed search

[1]

[2]

Coagulation factor II (thrombin) receptor-like 2, also known as F2RL2 or protease activated receptor 3 (PAR3), is a human gene.

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.^[1]

[edit] See also

Protease-activated receptor

[edit] References

^ Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2.

[edit] Further reading

Hollenberg MD, Compton SJ (2002). "International Union of Pharmacology. XXVIII. Proteinase-activated receptors.". Pharmacol. Rev. 54 (2): 203-17. PMID 12037136.
Ishihara H, Connolly AJ, Zeng D, et al. (1997). "Protease-activated receptor 3 is a second thrombin receptor in humans.". Nature 386 (6624): 502-6. doi:10.1038/386502a0. PMID 9087410.
Schmidt VA, Nierman WC, Maglott DR, et al. (1998). "The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets.". J. Biol. Chem. 273 (24): 15061-8. PMID 9614115.
Xu WF, Andersen H, Whitmore TE, et al. (1998). "Cloning and characterization of human protease-activated receptor 4.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642-6. PMID 9618465.
Guyonnet Dupérat V, Jacquelin B, Boisseau P, et al. (1998). "Protease-activated receptor genes are clustered on 5q13.". Blood 92 (1): 25-31. PMID 9639495.
Kahn ML, Zheng YW, Huang W, et al. (1998). "A dual thrombin receptor system for platelet activation.". Nature 394 (6694): 690-4. doi:10.1038/29325. PMID 9716134.
Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). "Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.". J. Biol. Chem. 273 (36): 23290-6. PMID 9722561.
Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.". J. Clin. Invest. 103 (6): 879-87. PMID 10079109.
Hauck RW, Schulz C, Schömig A, et al. (1999). "alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors.". Am. J. Physiol. 277 (1 Pt 1): L22-9. PMID 10409227.
Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). "PAR3 is a cofactor for PAR4 activation by thrombin.". Nature 404 (6778): 609-13. doi:10.1038/35007085. PMID 10766244.
O'Brien PJ, Prevost N, Molino M, et al. (2000). "Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.". J. Biol. Chem. 275 (18): 13502-9. PMID 10788464.
Cumashi A, Ansuini H, Celli N, et al. (2001). "Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets.". Thromb. Haemost. 85 (3): 533-8. PMID 11307827.
Sambrano GR, Weiss EJ, Zheng YW, et al. (2001). "Role of thrombin signalling in platelets in haemostasis and thrombosis.". Nature 413 (6851): 74-8. doi:10.1038/35092573. PMID 11544528.
Miike S, McWilliam AS, Kita H (2002). "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.". J. Immunol. 167 (11): 6615-22. PMID 11714832.
Uehara A, Sugawara S, Muramoto K, Takada H (2002). "Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2.". J. Immunol. 169 (8): 4594-603. PMID 12370398.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Even-Ram SC, Grisaru-Granovsky S, Pruss D, et al. (2003). "The pattern of expression of protease-activated receptors (PARs) during early trophoblast development.". J. Pathol. 200 (1): 47-52. doi:10.1002/path.1338. PMID 12692840.
Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin.". Biochem. Biophys. Res. Commun. 305 (1): 166-8. PMID 12732212.
Tanaka N, Morita T, Nezu A, et al. (2003). "Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1).". Life Sci. 73 (3): 301-10. PMID 12757837.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened