Glucagon-like peptide 1 receptor

From Wikipedia, the free encyclopedia

Identifiers

GLP1R; MGC138331

External IDs

OMIM: 138032 MGI: 99571 HomoloGene: 1558

Gene ontology
Molecular Function:	• G-protein coupled receptor activity • glucagon receptor activity • peptide receptor activity, G-protein coupled
Cellular Component:	• plasma membrane • integral to membrane
Biological Process:	• response to stress • signal transduction • G-protein coupled receptor protein signaling pathway • adenylate cyclase activation • elevation of cytosolic calcium ion concentration • learning and/or memory • regulation of heart contraction • cAMP-mediated signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002062 (mRNA)
NP_002053 (protein)

XM_001000702 (mRNA)
XP_001000702 (protein)

Location

Chr 6: 39.12 - 39.16 Mb

Chr 17: 30.63 - 30.66 Mb

Pubmed search

[1]

[2]

The gene for the glucagon-like peptide 1 receptor (GLP-1) receptor is on chromosome 6 and is known to be expressed in pancreatic beta cells.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Glucagon-like peptide-1

[edit] References

^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors" (^{[dead link]} – ^{Scholar search}). Recept. Channels 8 (3-4): 179–88. PMID 12529935.

[edit] Further reading

van Eyll B, Lankat-Buttgereit B, Bode HP, et al. (1994). "Signal transduction of the GLP-1-receptor cloned from a human insulinoma.". FEBS Lett. 348 (1): 7–13. PMID 7517895.
Gromada J, Rorsman P, Dissing S, Wulff BS (1995). "Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release.". FEBS Lett. 373 (2): 182–6. PMID 7589461.
Wei Y, Mojsov S (1995). "Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences.". FEBS Lett. 358 (3): 219–24. PMID 7843404.
Lankat-Buttgereit B, Göke R, Stöckmann F, et al. (1994). "Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes.". Digestion 55 (1): 29–33. PMID 8112494.
Graziano MP, Hey PJ, Borkowski D, et al. (1993). "Cloning and functional expression of a human glucagon-like peptide-1 receptor.". Biochem. Biophys. Res. Commun. 196 (1): 141–6. doi:10.1006/bbrc.1993.2226. PMID 8216285.
Stoffel M, Espinosa R, Le Beau MM, Bell GI (1993). "Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6.". Diabetes 42 (8): 1215–8. PMID 8392011.
Dillon JS, Tanizawa Y, Wheeler MB, et al. (1993). "Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor.". Endocrinology 133 (4): 1907–10. PMID 8404634.
Thorens B, Porret A, Bühler L, et al. (1993). "Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor.". Diabetes 42 (11): 1678–82. PMID 8405712.
Lankat-Buttgereit B, Göke B (1997). "Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene.". Peptides 18 (5): 617–24. PMID 9213353.
Frimurer TM, Bywater RP (1999). "Structure of the integral membrane domain of the GLP1 receptor.". Proteins 35 (4): 375–86. PMID 10382665.
Huypens P, Ling Z, Pipeleers D, Schuit F (2001). "Glucagon receptors on human islet cells contribute to glucose competence of insulin release.". Diabetologia 43 (8): 1012–9. PMID 10990079.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Xiao Q, Jeng W, Wheeler MB (2001). "Characterization of glucagon-like peptide-1 receptor-binding determinants.". J. Mol. Endocrinol. 25 (3): 321–35. PMID 11116211.
Bazarsuren A, Grauschopf U, Wozny M, et al. (2003). "In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor.". Biophys. Chem. 96 (2-3): 305–18. PMID 12034449.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Tokuyama Y, Matsui K, Egashira T, et al. (2005). "Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population.". Diabetes Res. Clin. Pract. 66 (1): 63–9. doi:10.1016/j.diabres.2004.02.004. PMID 15364163.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Jorgensen R, Martini L, Schwartz TW, Elling CE (2005). "Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype.". Mol. Endocrinol. 19 (3): 812–23. doi:10.1210/me.2004-0312. PMID 15528268.
Mahon MJ, Shimada M (2005). "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.". FEBS Lett. 579 (3): 803–7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850.

[edit] External links

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

Hidden categories: All articles with dead external links | Articles with dead external links since June 2008 | Protein pages needing a picture

See also ebooksgratis.com: no banners, no cookies, totally FREE.

Glucagon-like peptide 1 receptor

From Wikipedia, the free encyclopedia

Contents

[edit] See also

[edit] References

[edit] Further reading

[edit] External links

Views

Navigation

Interaction

Search