Sodium-hydrogen antiporter 1

From Wikipedia, the free encyclopedia

Solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)

PDB rendering based on 2bec.

Available structures: 2bec, 2e30

Identifiers

Symbol(s)

SLC9A1; APNH; FLJ42224; NHE1

External IDs

OMIM: 107310 MGI: 102462 HomoloGene: 20660

Gene ontology
Molecular Function:	• antiporter activity • solute:hydrogen antiporter activity • sodium:hydrogen antiporter activity • sodium ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• ion transport • sodium ion transport • regulation of pH

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003047 (mRNA)
NP_003038 (protein)

NM_016981 (mRNA)
NP_058677 (protein)

Location

Chr 1: 27.3 - 27.37 Mb

Chr 4: 132.64 - 132.7 Mb

Pubmed search

[1]

[2]

The Sodium-hydrogen antiporter 1 is an isoform of sodium-hydrogen antiporters.

[edit] Classification

It is a solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive),

[edit] Gene

It is encoded by the gene SLC9A1.

[edit] Further reading

Cingolani HE, Ennis IL (2007). "Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy.". Circulation 115 (9): 1090–100. doi:10.1161/CIRCULATIONAHA.106.626929. PMID 17339567.
Meima ME, Mackley JR, Barber DL (2007). "Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1.". Curr. Opin. Nephrol. Hypertens. 16 (4): 365–72. doi:10.1097/MNH.0b013e3281bd888d. PMID 17565280.
Tse CM, Ma AI, Yang VW, et al. (1991). "Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.". EMBO J. 10 (8): 1957–67. PMID 1712287.
Dudley CR, Giuffra LA, Tippett P, et al. (1991). "The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1.". Hum. Genet. 86 (1): 79–83. PMID 1979310.
Sardet C, Counillon L, Franchi A, Pouysségur J (1990). "Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD.". Science 247 (4943): 723–6. PMID 2154036.
Sardet C, Franchi A, Pouysségur J (1989). "Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.". Cell 56 (2): 271–80. PMID 2536298.
Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization.". Cytogenet. Cell Genet. 48 (1): 6–8. PMID 2846238.
Counillon L, Pouysségur J, Reithmeier RA (1994). "The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain.". Biochemistry 33 (34): 10463–9. PMID 8068684.
Fliegel L, Dyck JR, Wang H, et al. (1994). "Cloning and analysis of the human myocardial Na+/H+ exchanger.". Mol. Cell. Biochem. 125 (2): 137–43. PMID 8283968.
Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. PMID 8901634.
Shrode LD, Gan BS, D'Souza SJ, et al. (1998). "Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage.". Am. J. Physiol. 275 (2 Pt 1): C431–9. PMID 9688597.
Wakabayashi S, Pang T, Su X, Shigekawa M (2000). "A novel topology model of the human Na(+)/H(+) exchanger isoform 1.". J. Biol. Chem. 275 (11): 7942–9. PMID 10713111.
Garden OA, Musk P, Worthington-White DA, et al. (2000). "Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: A comparison with healthy controls.". Cancer Genet. Cytogenet. 120 (1): 37–43. PMID 10913675.
Denker SP, Huang DC, Orlowski J, et al. (2001). "Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation.". Mol. Cell 6 (6): 1425–36. PMID 11163215.
Lehoux S, Abe Ji , Florian JA, Berk BC (2001). "14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange.". J. Biol. Chem. 276 (19): 15794–800. doi:10.1074/jbc.M100410200. PMID 11279064.
Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers.". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
Yan W, Nehrke K, Choi J, Barber DL (2001). "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor.". J. Biol. Chem. 276 (33): 31349–56. doi:10.1074/jbc.M102679200. PMID 11369779.
Khaled AR, Moor AN, Li A, et al. (2001). "Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization.". Mol. Cell. Biol. 21 (22): 7545–57. doi:10.1128/MCB.21.22.7545-7557.2001. PMID 11604491.
Mailänder J, Müller-Esterl W, Dedio J (2001). "Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1.". FEBS Lett. 507 (3): 331–5. PMID 11696366.
Shen MR, Wilkins RJ, Chou CY, Ellory JC (2002). "Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells.". FEBS Lett. 512 (1-3): 52–8. PMID 11852051.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)

Categories: Genes on chromosome 1 | Human proteins | Membrane protein stubs | Solute carrier family

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Sodium-hydrogen antiporter 1

From Wikipedia, the free encyclopedia

[edit] Classification

[edit] Gene

[edit] Further reading

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