SLC1A2
From Wikipedia, the free encyclopedia
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Solute carrier family 1 (glial high affinity glutamate transporter), member 2
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| Identifiers | ||||||||||||||
| Symbol(s) | SLC1A2; EAAT2; GLT-1 | |||||||||||||
| External IDs | OMIM: 600300 MGI: 101931 HomoloGene: 3075 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 6506 | 20511 | ||||||||||||
| Ensembl | ENSG00000110436 | ENSMUSG00000005089 | ||||||||||||
| Uniprot | P43004 | Q3USU5 | ||||||||||||
| Refseq | NM_004171 (mRNA) NP_004162 (protein) |
NM_001077514 (mRNA) NP_001070982 (protein) |
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| Location | Chr 11: 35.23 - 35.4 Mb | Chr 2: 102.46 - 102.58 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Solute carrier family 1 (glial high affinity glutamate transporter), member 2, also known as SLC1A2, is a human gene.[1]
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.[1]
[edit] See also
[edit] References
[edit] Further reading
- Wang Z, Trillo-Pazos G, Kim SY, et al. (2004). "Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis.". J. Neurovirol. 10 Suppl 1: 25–32. PMID 14982736.
- Arriza JL, Fairman WA, Wadiche JI, et al. (1994). "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.". J. Neurosci. 14 (9): 5559–69. PMID 7521911.
- Manfras BJ, Rudert WA, Trucco M, Boehm BO (1994). "Cloning and characterization of a glutamate transporter cDNA from human brain and pancreas.". Biochim. Biophys. Acta 1195 (1): 185–8. PMID 7522567.
- Li X, Francke U (1995). "Assignment of the gene SLC1A2 coding for the human glutamate transporter EAAT2 to human chromosome 11 bands p13-p12.". Cytogenet. Cell Genet. 71 (3): 212–3. PMID 7587378.
- Shashidharan P, Wittenberg I, Plaitakis A (1994). "Molecular cloning of human brain glutamate/aspartate transporter II.". Biochim. Biophys. Acta 1191 (2): 393–6. PMID 8172925.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
- Milton ID, Banner SJ, Ince PG, et al. (1998). "Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study.". Brain Res. Mol. Brain Res. 52 (1): 17–31. PMID 9450673.
- Shimamoto K, Lebrun B, Yasuda-Kamatani Y, et al. (1998). "DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.". Mol. Pharmacol. 53 (2): 195–201. PMID 9463476.
- Lin CL, Bristol LA, Jin L, et al. (1998). "Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis.". Neuron 20 (3): 589–602. PMID 9539131.
- Aoki M, Lin CL, Rothstein JD, et al. (1998). "Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis.". Ann. Neurol. 43 (5): 645–53. doi:. PMID 9585360.
- Trotti D, Aoki M, Pasinelli P, et al. (2001). "Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity.". J. Biol. Chem. 276 (1): 576–82. doi:. PMID 11031254.
- Münch C, Schwalenstöcker B, Hermann C, et al. (2001). "Differential RNA cleavage and polyadenylation of the glutamate transporter EAAT2 in the human brain.". Brain Res. Mol. Brain Res. 80 (2): 244–51. PMID 11038258.
- Honig LS, Chambliss DD, Bigio EH, et al. (2000). "Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls.". Neurology 55 (8): 1082–8. PMID 11071482.
- Flowers JM, Powell JF, Leigh PN, et al. (2001). "Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis.". Ann. Neurol. 49 (5): 643–9. PMID 11357955.
- Rimaniol AC, Mialocq P, Clayette P, et al. (2001). "Role of glutamate transporters in the regulation of glutathione levels in human macrophages.". Am. J. Physiol., Cell Physiol. 281 (6): C1964–70. PMID 11698255.
- Tozaki H, Kanno T, Nomura T, et al. (2002). "Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission.". Brain Res. Mol. Brain Res. 97 (1): 7–12. PMID 11744157.
- Palmada M, Kinne-Saffran E, Centelles JJ, Kinne RK (2002). "Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells.". Neurochem. Int. 40 (4): 321–6. PMID 11792462.
- Marie H, Billups D, Bedford FK, et al. (2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba.". Mol. Cell. Neurosci. 19 (2): 152–64. doi:. PMID 11860269.
- Reye P, Sullivan R, Fletcher EL, Pow DV (2002). "Distribution of two splice variants of the glutamate transporter GLT1 in the retinas of humans, monkeys, rabbits, rats, cats, and chickens.". J. Comp. Neurol. 445 (1): 1–12. PMID 11891650.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
