SLC2A10

From Wikipedia, the free encyclopedia

Solute carrier family 2 (facilitated glucose transporter), member 10

Identifiers

SLC2A10; ATS; GLUT10; MGC126706

External IDs

OMIM: 606145 MGI: 2156687 HomoloGene: 38551

Gene ontology
Molecular Function:	• transporter activity • sugar:hydrogen ion symporter activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• carbohydrate transport • glucose transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030777 (mRNA)
NP_110404 (protein)

NM_130451 (mRNA)
NP_569718 (protein)

Location

Chr 20: 44.77 - 44.8 Mb

Chr 2: 165.2 - 165.21 Mb

Pubmed search

[1]

[2]

Solute carrier family 2 (facilitated glucose transporter), member 10, also known as SLC2A10, is a human gene.^[1]

SLC2A10 is a member of the facilitative glucose transporter family, which plays a significant role in maintaining glucose homeostasis.[supplied by OMIM]^[1]

[edit] See also

[edit] References

^ ^a ^b Entrez Gene: SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10.

[edit] Further reading

McVie-Wylie AJ, Lamson DR, Chen YT (2001). "Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility.". Genomics 72 (1): 113-7. doi:10.1006/geno.2000.6457. PMID 11247674.
Dawson PA, Mychaleckyj JC, Fossey SC, et al. (2001). "Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1.". Mol. Genet. Metab. 74 (1-2): 186-99. doi:10.1006/mgme.2001.3212. PMID 11592815.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Richardson S, Neama G, Phillips T, et al. (2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation.". Osteoarthr. Cartil. 11 (2): 92-101. PMID 12554125.
Wood IS, Hunter L, Trayhurn P (2003). "Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues.". Biochem. Biophys. Res. Commun. 308 (1): 43-9. PMID 12890477.
Andersen G, Rose CS, Hamid YH, et al. (2003). "Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits.". Diabetes 52 (9): 2445-8. PMID 12941788.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zaidi SH, Peltekova V, Meyer S, et al. (2005). "A family exhibiting arterial tortuosity syndrome displays homozygosity for markers in the arterial tortuosity locus at chromosome 20q13.". Clin. Genet. 67 (2): 183-8. doi:10.1111/j.1399-0004.2004.00391.x. PMID 15679832.
Mohlke KL, Skol AD, Scott LJ, et al. (2005). "Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns.". Mol. Genet. Metab. 85 (4): 323-7. doi:10.1016/j.ymgme.2005.04.011. PMID 15936967.
Segade F, Allred DC, Bowden DW (2005). "Functional characterization of the promoter of the human glucose transporter 10 gene.". Biochim. Biophys. Acta 1730 (2): 147-58. doi:10.1016/j.bbaexp.2005.06.012. PMID 16051383.
Coucke PJ, Willaert A, Wessels MW, et al. (2006). "Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome.". Nat. Genet. 38 (4): 452-7. doi:10.1038/ng1764. PMID 16550171.
Lin WH, Chuang LM, Chen CH, et al. (2006). "Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population.". Diabetologia 49 (6): 1214-21. doi:10.1007/s00125-006-0218-3. PMID 16586067.

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)