SLC16A4

From Wikipedia, the free encyclopedia

Solute carrier family 16, member 4 (monocarboxylic acid transporter 5)

Identifiers

SLC16A4; MCT5; MCT4

External IDs

OMIM: 603878 MGI: 2385183 HomoloGene: 74529

Gene ontology
Molecular Function:	• transporter activity • monocarboxylic acid transmembrane transporter activity • symporter activity
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane
Biological Process:	• transport • monocarboxylic acid transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004696 (mRNA)
NP_004687 (protein)

NM_146136 (mRNA)
NP_666248 (protein)

Location

Chr 1: 110.71 - 110.74 Mb

Chr 3: 107.42 - 107.44 Mb

Pubmed search

[1]

[2]

Solute carrier family 16, member 4 (monocarboxylic acid transporter 5), also known as SLC16A4, is a human gene.^[1]

[edit] See also

Solute carrier family

[edit] References

^ Entrez Gene: SLC16A4 solute carrier family 16, member 4 (monocarboxylic acid transporter 5).

[edit] Further reading

Halestrap AP, Price NT (1999). "The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.". Biochem. J. 343 Pt 2: 281–99. PMID 10510291.
Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.". Pflugers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Price NT, Jackson VN, Halestrap AP (1998). "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.". Biochem. J. 329 ( Pt 2): 321–8. PMID 9425115.
Pilegaard H, Terzis G, Halestrap A, Juel C (1999). "Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle.". Am. J. Physiol. 276 (5 Pt 1): E843–8. PMID 10329977.
Manning Fox JE, Meredith D, Halestrap AP (2001). "Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle.". J. Physiol. (Lond.) 529 Pt 2: 285–93. PMID 11101640.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. PMID 12657613.
Juel C, Holten MK, Dela F (2004). "Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans.". J. Physiol. (Lond.) 556 (Pt 1): 297–304. doi:10.1113/jphysiol.2003.058222. PMID 14724187.
Settle P, Mynett K, Speake P, et al. (2004). "Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta.". Placenta 25 (6): 496–504. doi:10.1016/j.placenta.2003.11.009. PMID 15135232.
Wilson MC, Meredith D, Fox JE, et al. (2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).". J. Biol. Chem. 280 (29): 27213–21. doi:10.1074/jbc.M411950200. PMID 15917240.
Merezhinskaya N, Ogunwuyi SA, Fishbein WN (2006). "Expression of monocarboxylate transporter 4 in human platelets, leukocytes, and tissues assessed by antibodies raised against terminal versus pre-terminal peptides.". Mol. Genet. Metab. 87 (2): 152–61. doi:10.1016/j.ymgme.2005.09.029. PMID 16403666.
Bickham DC, Bentley DJ, Le Rossignol PF, Cameron-Smith D (2006). "The effects of short-term sprint training on MCT expression in moderately endurance-trained runners.". Eur. J. Appl. Physiol. 96 (6): 636–43. doi:10.1007/s00421-005-0100-x. PMID 16408234.
Ullah MS, Davies AJ, Halestrap AP (2006). "The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.". J. Biol. Chem. 281 (14): 9030–7. doi:10.1074/jbc.M511397200. PMID 16452478.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Bishop D, Edge J, Thomas C, Mercier J (2007). "High-intensity exercise acutely decreases the membrane content of MCT1 and MCT4 and buffer capacity in human skeletal muscle.". J. Appl. Physiol. 102 (2): 616–21. doi:10.1152/japplphysiol.00590.2006. PMID 17082373.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)