ABCC1
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ATP-binding cassette, sub-family C (CFTR/MRP), member 1
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| PDB rendering based on 2cbz. | ||||||||||||||
| Available structures: 2cbz | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | ABCC1; MRP1; ABC29; ABCC; DKFZp686N04233; DKFZp781G125; GS-X; MRP | |||||||||||||
| External IDs | OMIM: 158343 MGI: 102676 HomoloGene: 55459 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 4363 | 17250 | ||||||||||||
| Ensembl | ENSG00000103222 | ENSMUSG00000023088 | ||||||||||||
| Uniprot | P33527 | Q3UDM1 | ||||||||||||
| Refseq | NM_004996 (mRNA) NP_004987 (protein) |
NM_008576 (mRNA) NP_032602 (protein) |
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| Location | Chr 16: 16.01 - 16.14 Mb | Chr 16: 14.28 - 14.39 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
ATP-binding cassette, sub-family C (CFTR/MRP), member 1, also known as ABCC1, is a human gene.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Lautier D, Canitrot Y, Deeley RG, Cole SP (1996). "Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.". Biochem. Pharmacol. 52 (7): 967–77. PMID 8831715.
- Deeley RG, Cole SP (1998). "Function, evolution and structure of multidrug resistance protein (MRP).". Semin. Cancer Biol. 8 (3): 193–204. doi:. PMID 9441948.
- Hegedus T, Orfi L, Seprodi A, et al. (2002). "Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.". Biochim. Biophys. Acta 1587 (2-3): 318–25. PMID 12084474.
- Chang XB (2007). "A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1.". Cancer Metastasis Rev. 26 (1): 15–37. doi:. PMID 17295059.
[edit] External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
