SLC10A2

From Wikipedia, the free encyclopedia

Solute carrier family 10 (sodium/bile acid cotransporter family), member 2

Identifiers

SLC10A2; ASBT; ISBT; NTCP2

External IDs

OMIM: 601295 MGI: 1201406 HomoloGene: 390

Gene ontology
Molecular Function:	• bile acid:sodium symporter activity • symporter activity • sodium ion binding
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• ion transport • sodium ion transport • organic anion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000452 (mRNA)
NP_000443 (protein)

NM_011388 (mRNA)
NP_035518 (protein)

Location

Chr 13: 102.49 - 102.52 Mb

Chr 8: 5.09 - 5.11 Mb

Pubmed search

[1]

[2]

Solute carrier family 10 (sodium/bile acid cotransporter family), member 2, also known as SLC10A2, is a human gene.^[1]

[edit] See also

Solute carrier family

[edit] References

^ Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2.

[edit] Further reading

Shneider BL (2001). "Intestinal bile acid transport: biology, physiology, and pathophysiology.". J. Pediatr. Gastroenterol. Nutr. 32 (4): 407-17. PMID 11396803.
Balakrishnan A, Polli JE (2006). "Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target.". Mol. Pharm. 3 (3): 223-30. doi:10.1021/mp060022d. PMID 16749855.
Wong MH, Oelkers P, Dawson PA (1995). "Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity.". J. Biol. Chem. 270 (45): 27228-34. PMID 7592981.
Wong MH, Rao PN, Pettenati MJ, Dawson PA (1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33.". Genomics 33 (3): 538-40. doi:10.1006/geno.1996.0233. PMID 8661017.
Oelkers P, Kirby LC, Heubi JE, Dawson PA (1997). "Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).". J. Clin. Invest. 99 (8): 1880-7. PMID 9109432.
Craddock AL, Love MW, Daniel RW, et al. (1998). "Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.". Am. J. Physiol. 274 (1 Pt 1): G157-69. PMID 9458785.
Montagnani M, Love MW, Rössel P, et al. (2002). "Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption.". Scand. J. Gastroenterol. 36 (10): 1077-80. PMID 11589382.
Love MW, Craddock AL, Angelin B, et al. (2002). "Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia.". Arterioscler. Thromb. Vasc. Biol. 21 (12): 2039-45. PMID 11742882.
Jung D, Fried M, Kullak-Ublick GA (2002). "Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha.". J. Biol. Chem. 277 (34): 30559-66. doi:10.1074/jbc.M203511200. PMID 12055195.
Zelcer N, Saeki T, Bot I, et al. (2003). "Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter.". Biochem. J. 369 (Pt 1): 23-30. doi:10.1042/BJ20021081. PMID 12220224.
Chumakov I, Blumenfeld M, Guerassimenko O, et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675-80. doi:10.1073/pnas.182412499. PMID 12364586.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
Neimark E, Chen F, Li X, Shneider BL (2004). "Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.". Hepatology 40 (1): 149-56. doi:10.1002/hep.20295. PMID 15239098.
Xia X, Roundtree M, Merikhi A, et al. (2004). "Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes.". J. Biol. Chem. 279 (43): 44931-7. doi:10.1074/jbc.M400969200. PMID 15304498.
Zhang EY, Phelps MA, Banerjee A, et al. (2004). "Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).". Biochemistry 43 (36): 11380-92. doi:10.1021/bi049270a. PMID 15350125.
Banerjee A, Ray A, Chang C, Swaan PW (2005). "Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2).". Biochemistry 44 (24): 8908-17. doi:10.1021/bi050553s. PMID 15952798.
Nakahara M, Furuya N, Takagaki K, et al. (2006). "Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine.". J. Biol. Chem. 280 (51): 42283-9. doi:10.1074/jbc.M507454200. PMID 16230354.
Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers.". J. Lipid Res. 47 (1): 42-50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.
Banerjee A, Swaan PW (2006). "Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains.". Biochemistry 45 (3): 943-53. doi:10.1021/bi052202j. PMID 16411770.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)