Sodium-glucose transport proteins

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Sodium-dependent glucose cotransporters are a family of glucose transporter found in the intestinal mucosa of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 and SGLT1). They contribute to renal glucose reabsorption.

[edit] Types

SGLT1 and SGLT2 are members of the SLC5A gene family.

Including SGLT1 and SGLT2, there are total seven members in the human protein family SLC5A, several of which may also be sodium-glucose transporters^[3].

[edit] Functions

These proteins use the energy from a downhill sodium gradient to transport glucose across the apical membrane against an uphill glucose gradient. Therefore, these co-transporters are an example of secondary active transport. (The GLUT uniporters then transport the glucose across the basolateral membrane, into the peritubular capillaries.)

[edit] See also

• Glucose-galactose malabsorption

[edit] References

1. ^ Wright EM, Hirayama BA, Loo DF. (2007) "Active sugar transport in health and disease", J Intern Med, 261:32–43
2. ^ Wright EM. (2001) "Renal Na+-glucose cotransporters", Am J Physiol Renal Physiol, 280:F10–F18
3. ^ Ensembl release 48: Homo sapiens Ensembl protein family ENSF00000000509

[edit] External links

• MeSH Sodium-Glucose+Transport+Proteins

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