SLC10A1

From Wikipedia, the free encyclopedia

Solute carrier family 10 (sodium/bile acid cotransporter family), member 1

Identifiers

SLC10A1; NTCP; NTCP1

External IDs

OMIM: 182396 MGI: 97379 HomoloGene: 31126

Gene ontology
Molecular Function:	• bile acid:sodium symporter activity • symporter activity • sodium ion binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• ion transport • sodium ion transport • organic anion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003049 (mRNA)
NP_003040 (protein)

NM_011387 (mRNA)
NP_035517 (protein)

Location

Chr 14: 69.31 - 69.33 Mb

Chr 12: 81.87 - 81.89 Mb

Pubmed search

[1]

[2]

Solute carrier family 10 (sodium/bile acid cotransporter family), member 1, also known as SLC10A1 or the Na⁺-taurocholate cotransporting polypeptide (NTCP), is a human gene.^[1]

Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization (SLC10A2; MIM 601295), and the other being found in the basolateral membranes of hepatocytes (SLC10A1).[supplied by OMIM]^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1.

[edit] Further reading

Trauner M, Boyer JL (2003). "Bile salt transporters: molecular characterization, function, and regulation.". Physiol. Rev. 83 (2): 633-71. doi:10.1152/physrev.00027.2002. PMID 12663868.
Hagenbuch B, Meier PJ (1994). "Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.". J. Clin. Invest. 93 (3): 1326-31. PMID 8132774.
Shiao T, Iwahashi M, Fortune J, et al. (2001). "Structural and functional characterization of liver cell-specific activity of the human sodium/taurocholate cotransporter.". Genomics 69 (2): 203-13. doi:10.1006/geno.2000.6329. PMID 11031103.
Müller O, Schalla C, Scheibner J, et al. (2002). "Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant mice.". Biochem. J. 361 (Pt 3): 673-9. PMID 11802798.
Hallén S, Mareninova O, Brändén M, Sachs G (2002). "Organization of the membrane domain of the human liver sodium/bile acid cotransporter.". Biochemistry 41 (23): 7253-66. PMID 12044156.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ho RH, Leake BF, Roberts RL, et al. (2004). "Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition.". J. Biol. Chem. 279 (8): 7213-22. doi:10.1074/jbc.M305782200. PMID 14660639.
Jung D, Hagenbuch B, Fried M, et al. (2004). "Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene.". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (5): G752-61. doi:10.1152/ajpgi.00456.2003. PMID 14701722.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Alrefai WA, Sarwar Z, Tyagi S, et al. (2005). "Cholesterol modulates human intestinal sodium-dependent bile acid transporter.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (5): G978-85. doi:10.1152/ajpgi.00379.2004. PMID 15604201.
Chen HL, Chen HL, Liu YJ, et al. (2005). "Developmental expression of canalicular transporter genes in human liver.". J. Hepatol. 43 (3): 472-7. doi:10.1016/j.jhep.2005.02.030. PMID 15922475.
Anwer MS, Gillin H, Mukhopadhyay S, et al. (2005). "Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp.". J. Biol. Chem. 280 (39): 33687-92. doi:10.1074/jbc.M502151200. PMID 16027164.
Eloranta JJ, Jung D, Kullak-Ublick GA (2006). "The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism.". Mol. Endocrinol. 20 (1): 65-79. doi:10.1210/me.2005-0159. PMID 16123152.
Dias V, Ribeiro V (2007). "The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells.". Fundamental & clinical pharmacology 21 (4): 445-50. doi:10.1111/j.1472-8206.2007.00517.x. PMID 17635184.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)