SOX13

From Wikipedia, the free encyclopedia

SRY (sex determining region Y)-box 13

PDB rendering based on 1i11.

Available structures: 1i11

Identifiers

Symbol(s)

SOX13; ICA12; MGC117216; SRY-box 13; Sox-13

External IDs

OMIM: 604748 MGI: 98361 HomoloGene: 4159

Gene ontology
Molecular Function:	• transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • anatomical structure morphogenesis

Orthologs

Human

Mouse

Refseq

NM_005686 (mRNA)
NP_005677 (protein)

NM_011439 (mRNA)
NP_035569 (protein)

Location

Chr 1: 202.31 - 202.36 Mb

Chr 1: 135.21 - 135.22 Mb

Pubmed search

[1]

[2]

SRY (sex determining region Y)-box 13, also known as SOX13, is a human gene.^[1]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

SOX genes

[edit] References

^ ^a ^b Entrez Gene: SOX13 SRY (sex determining region Y)-box 13.

[edit] Further reading

Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev. 12 (4): 441–6. PMID 12100890.
Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. PMID 12194848.
Roose J, Korver W, Oving E, et al. (1998). "High expression of the HMG box factor sox-13 in arterial walls during embryonic development.". Nucleic Acids Res. 26 (2): 469–76. PMID 9421502.
Roose J, Korver W, de Boer R, et al. (1999). "The Sox-13 gene: structure, promoter characterization, and chromosomal localization.". Genomics 57 (2): 301–5. doi:10.1006/geno.1999.5779. PMID 10198172.
Argentaro A, Olsson J, Critcher R, et al. (2000). "Genomic characterisation and fine mapping of the human SOX13 gene.". Gene 250 (1-2): 181–9. PMID 10854791.
Kasimiotis H, Myers MA, Argentaro A, et al. (2000). "Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets.". Diabetes 49 (4): 555–61. PMID 10871192.
Steinbrenner H, Lohmann T, Ostendorf B, et al. (2001). "Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes.". Diabetologia 43 (11): 1381–4. PMID 11126406.
Kasimiotis H, Fida S, Rowley MJ, et al. (2001). "Antibodies to SOX13 (ICA12) are associated with type 1 diabetes.". Autoimmunity 33 (2): 95–101. PMID 11264788.
Lampasona V, Scirpoli M, Bosi E, Bonifacio E (2001). "ICA12(SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical Type I diabetes.". Diabetologia 44 (2): 267. PMID 11270687.
Argentaro A, Wapelhorst B, Concannon P, Harley VR (2001). "Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes.". Mol. Genet. Metab. 72 (4): 356–9. doi:10.1006/mgme.2000.3136. PMID 11286511.
Fida S, Myers M, Mackay IR, et al. (2001). "Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: prevalence of anti-ICA512/IA2 and anti-SOX13.". Diabetes Res. Clin. Pract. 52 (3): 205–11. PMID 11323090.
Tandon N, Shtauvere-Brameus A, Hagopian WA, Sanjeevi CB (2002). "Prevalence of ICA-12 and other autoantibodies in north Indian patients with early-onset diabetes.". Ann. N. Y. Acad. Sci. 958: 214–7. PMID 12021109.
Törn C, Shtauvere-Brameus A, Sanjeevi CB, Landin-Olsson M (2002). "Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.". Ann. N. Y. Acad. Sci. 958: 218–23. PMID 12021110.
Shtauvere-Brameus A, Hagopian W, Rumba I, Sanjeevi CB (2002). "Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients.". Ann. N. Y. Acad. Sci. 958: 297–304. PMID 12021128.
Gupta M, Tandon N, Shtauvere-Brameus A, Sanjeevi CB (2002). "ICA12 autoantibodies are associated with non-DR3/non-DR4 in patients with latent autoimmune diabetes in adults from northern India.". Ann. N. Y. Acad. Sci. 958: 329–32. PMID 12021135.
Fida S, Myers MA, Whittingham S, et al. (2003). "Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases.". J. Autoimmun. 19 (4): 251–7. PMID 12473246.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Park Y, Park H, Yoo E, Kim D (2004). "SOX13 autoantibodies are likely to be a supplementary marker for type 1 diabetes in Korea.". Ann. N. Y. Acad. Sci. 1005: 253–8. PMID 14679071.

[edit] External links

MeSH SOX13+protein,+human

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD

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SOX13

From Wikipedia, the free encyclopedia

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[edit] References

[edit] Further reading

[edit] External links

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