POU4F1

From Wikipedia, the free encyclopedia

POU domain, class 4, transcription factor 1

Identifiers

POU4F1; BRN3A; FLJ13449; Oct-T1; RDC-1

External IDs

OMIM: 601632 MGI: 102525 HomoloGene: 21255

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription from RNA polymerase II promoter • multicellular organismal development • axonogenesis • synaptogenesis • neuron differentiation • positive regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001133287 (mRNA)
XP_001133287 (protein)

XM_001006853 (mRNA)
XP_001006853 (protein)

Location

Chr 13: 78.07 - 78.08 Mb

Chr 14: 103.35 - 103.35 Mb

Pubmed search

[1]

[2]

POU domain, class 4, transcription factor 1, also known as POU4F1, is a human gene.^[1]

BRN3A (POU4F1) is a class IV POU domain-containing transcription factor highly expressed in the developing sensory nervous system and in cells of the B- and T-lymphocytic lineages (Gerrero et al., 1993).[supplied by OMIM]^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

BRN-3

[edit] References

^ ^a ^b Entrez Gene: POU4F1 POU domain, class 4, transcription factor 1.

[edit] Further reading

Collum RG, Fisher PE, Datta M, et al. (1992). "A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.". Nucleic Acids Res. 20 (18): 4919–25. PMID 1357630.
Xiang M, Zhou L, Macke JP, et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.". J. Neurosci. 15 (7 Pt 1): 4762–85. PMID 7623109.
Bhargava AK, Li Z, Weissman SM (1993). "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 10260–4. PMID 8234287.
Gerrero MR, McEvilly RJ, Turner E, et al. (1993). "Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10841–5. PMID 8248179.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Still IH, Cowell J (1996). "The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis.". Cytogenet. Cell Genet. 74 (3): 225–6. PMID 8941380.
Smith MD, Dawson SJ, Latchman DS (1997). "Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor.". J. Biol. Chem. 272 (2): 1382–8. PMID 8995448.
Budhram-Mahadeo V, Parker M, Latchman DS (1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.". Mol. Cell. Biol. 18 (2): 1029–41. PMID 9448000.
Frass B, Vassen L, Möröy T (2003). "Gene expression of the POU factor Brn-3a is regulated by two different promoters.". Biochim. Biophys. Acta 1579 (2-3): 207–13. PMID 12427558.
Thomas GR, Latchman DS (2003). "The pro-oncoprotein EWS (Ewing's Sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription.". Cancer Biol. Ther. 1 (4): 428–32. PMID 12432261.
Trieu M, Ma A, Eng SR, et al. (2003). "Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a.". Development 130 (1): 111–21. PMID 12441296.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ma L, Lei L, Eng SR, et al. (2003). "Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons.". Development 130 (15): 3525–34. PMID 12810599.
Sindos M, Ndisang D, Pisal N, et al. (2003). "Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia.". Gynecol. Oncol. 90 (2): 366–71. PMID 12893201.
Sindos M, Ndisang D, Pisal N, et al. (2004). "Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality.". Int. J. Gynecol. Cancer 13 (4): 515–7. PMID 12911730.
Calissano M, Latchman DS (2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.". Oncogene 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. PMID 12934100.
Gascoyne DM, Thomas GR, Latchman DS (2004). "The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1.". Oncogene 23 (21): 3830–40. doi:10.1038/sj.onc.1207497. PMID 15021903.
Farooqui-Kabir SR, Budhram-Mahadeo V, Lewis H, et al. (2005). "Regulation of Hsp27 expression and cell survival by the POU transcription factor Brn3a.". Cell Death Differ. 11 (11): 1242–4. doi:10.1038/sj.cdd.4401478. PMID 15272315.
Ndisang D, Faulkes DJ, Gascoyne D, et al. (2006). "Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a.". Oncogene 25 (1): 51–60. doi:10.1038/sj.onc.1209006. PMID 16247485.
Diss JK, Faulkes DJ, Walker MM, et al. (2006). "Brn-3a neuronal transcription factor functional expression in human prostate cancer.". Prostate Cancer Prostatic Dis. 9 (1): 83–91. doi:10.1038/sj.pcan.4500837. PMID 16276351.

[edit] External links

MeSH POU4F1+protein,+human

This article on a gene on chromosome 13 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD