MAF (gene)

From Wikipedia, the free encyclopedia

V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

Identifiers

MAF; MGC71685

External IDs

OMIM: 177075 MGI: 96909 HomoloGene: 74552

Gene ontology
Molecular Function:	• transcription factor activity • RNA polymerase II transcription factor activity • sequence-specific DNA binding • protein dimerization activity
Cellular Component:	• chromatin • nucleus • cytoplasm
Biological Process:	• cytokine production • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001134279 (mRNA)
XP_001134279 (protein)

XM_001001001 (mRNA)
XP_001001001 (protein)

Location

Chr 16: 78.19 - 78.19 Mb

Chr 8: 118.58 - 118.59 Mb

Pubmed search

[1]

[2]

MAF (V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)), is a transcription factor, but also denotes the human gene encoding it.^[1]

1 Types
2 References
3 Further reading
4 External links

[edit] Types

One type, MafA, also known as RIPE3b1^[2], promotes pancreatic development, as well as insulin gene transcription^[3]

[edit] References

^ Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian).
^ Olbrot M, Rud J, Moss LG, Sharma A (2002). "Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6737–42. doi:10.1073/pnas.102168499. PMID 12011435.
^ Melloul et al., Diabetologica, 45, 309-326, year 2002. Regulation of insulin gene transcription

[edit] Further reading

Kerppola TK, Curran T (1994). "Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun.". Oncogene 9 (3): 675–84. PMID 8108109.
Kurschner C, Morgan JI (1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity.". Biochem. Biophys. Res. Commun. 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273.
Hedge SP, Kumar A, Kurschner C, Shapiro LH (1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation.". Mol. Cell. Biol. 18 (5): 2729–37. PMID 9566892.
Chesi M, Bergsagel PL, Shonukan OO, et al. (1998). "Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma.". Blood 91 (12): 4457–63. PMID 9616139.
Christodoulopoulos P, Cameron L, Nakamura Y, et al. (2001). "TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression.". J. Allergy Clin. Immunol. 107 (4): 586–91. doi:10.1067/mai.2001.114883. PMID 11295643.
Jamieson RV, Perveen R, Kerr B, et al. (2002). "Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma.". Hum. Mol. Genet. 11 (1): 33–42. PMID 11772997.
Chen Q, Dowhan DH, Liang D, et al. (2002). "CREB-binding protein/p300 co-activation of crystallin gene expression.". J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779.
Dhakshinamoorthy S, Jaiswal AK (2002). "c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction.". Oncogene 21 (34): 5301–12. doi:10.1038/sj.onc.1205642. PMID 12149651.
Cousins DJ, Lee TH, Staynov DZ (2002). "Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines.". J. Immunol. 169 (5): 2498–506. PMID 12193719.
Huang W, Lu N, Eberspaecher H, De Crombrugghe B (2003). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene.". J. Biol. Chem. 277 (52): 50668–75. doi:10.1074/jbc.M206544200. PMID 12381733.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG (2003). "Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice.". Mol. Vis. 9: 288–94. PMID 12835653.
Grimbert P, Valanciute A, Audard V, et al. (2003). "Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization.". J. Exp. Med. 198 (5): 797–807. doi:10.1084/jem.20030566. PMID 12939343.
Valanciuté A, le Gouvello S, Solhonne B, et al. (2004). "NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome.". J. Immunol. 172 (1): 688–98. PMID 14688382.
Rasmussen T, Knudsen LM, Dahl IM, Johnsen HE (2004). "C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance.". Leuk. Lymphoma 44 (10): 1761–6. PMID 14692531.
Hurt EM, Wiestner A, Rosenwald A, et al. (2004). "Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.". Cancer Cell 5 (2): 191–9. PMID 14998494.
Cao S, Liu J, Song L, Ma X (2005). "The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages.". J. Immunol. 174 (6): 3484–92. PMID 15749884.
Morito N, Yoh K, Fujioka Y, et al. (2006). "Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human.". Cancer Res. 66 (2): 812–9. doi:10.1158/0008-5472.CAN-05-2154. PMID 16424013.
Vanita V, Singh D, Robinson PN, et al. (2006). "A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract" in an Indian family.". Am. J. Med. Genet. A 140 (6): 558–66. doi:10.1002/ajmg.a.31126. PMID 16470690.

[edit] External links

MeSH MAF+protein,+human

This article on a gene on chromosome 16 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1

(1.3) bHLH-ZIP	MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)

(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)

(2.3) Cys₂His₂	ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2

(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53

(4.4) MADS box	Mef2 (A, B, C, D) • SRF

(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1

(0.3) Pocket domain	Rb • RBL1 • RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 • EREBP • B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD