HIC1
From Wikipedia, the free encyclopedia
Hypermethylated in cancer 1
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Identifiers | ||||||||||||||
Symbol(s) | HIC1; ZBTB29; hic-1 | |||||||||||||
External IDs | OMIM: 603825 MGI: 1338010 HomoloGene: 4740 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 3090 | 15248 | ||||||||||||
Ensembl | ENSG00000177374 | ENSMUSG00000043099 | ||||||||||||
Uniprot | Q14526 | Q5NCQ8 | ||||||||||||
Refseq | NM_006497 (mRNA) NP_006488 (protein) |
XM_001000715 (mRNA) XP_001000715 (protein) |
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Location | Chr 17: 1.91 - 1.91 Mb | Chr 11: 74.98 - 74.99 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Hypermethylated in cancer 1, also known as HIC1, is a human gene.[1]
[edit] References
[edit] Further reading
- Chopin V, Leprince D (2006). "[Chromosome arm 17p13.3: could HIC1 be the one ?]". Med Sci (Paris) 22 (1): 54-61. PMID 16386221.
- Wales MM, Biel MA, el Deiry W, et al. (1995). "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.". Nat. Med. 1 (6): 570-7. PMID 7585125.
- Fujii H, Biel MA, Zhou W, et al. (1998). "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer.". Oncogene 16 (16): 2159-64. doi: . PMID 9572497.
- Deltour S, Guerardel C, Stehelin D, Leprince D (1999). "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved.". Biochim. Biophys. Acta 1443 (1-2): 230-2. PMID 9838134.
- Deltour S, Guerardel C, Leprince D (2000). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14831-6. PMID 10611298.
- Guerardel C, Deltour S, Pinte S, et al. (2001). "Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53.". J. Biol. Chem. 276 (5): 3078-89. doi: . PMID 11073960.
- Deltour S, Pinte S, Guérardel C, Leprince D (2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1.". Biochem. Biophys. Res. Commun. 287 (2): 427-34. doi: . PMID 11554746.
- Deltour S, Pinte S, Guerardel C, et al. (2002). "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif.". Mol. Cell. Biol. 22 (13): 4890-901. PMID 12052894.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi: . PMID 12477932.
- Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918-30. PMID 12621583.
- Rathi A, Virmani AK, Harada K, et al. (2004). "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms.". Clin. Cancer Res. 9 (10 Pt 1): 3674-8. PMID 14506157.
- Waha A, Waha A, Koch A, et al. (2004). "Epigenetic silencing of the HIC-1 gene in human medulloblastomas.". J. Neuropathol. Exp. Neurol. 62 (11): 1192-201. PMID 14656076.
- Lindsey JC, Lusher ME, Anderton JA, et al. (2004). "Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.". Carcinogenesis 25 (5): 661-8. doi: . PMID 14688019.
- Pinte S, Guérardel C, Deltour-Balerdi S, et al. (2004). "Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1.". Oncogene 23 (22): 4023-31. doi: . PMID 15007385.
- Pinte S, Stankovic-Valentin N, Deltour S, et al. (2004). "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.". J. Biol. Chem. 279 (37): 38313-24. doi: . PMID 15231840.
- Chen W, Cooper TK, Zahnow CA, et al. (2004). "Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.". Cancer Cell 6 (4): 387-98. doi: . PMID 15488761.
- Britschgi C, Rizzi M, Grob TJ, et al. (2006). "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1.". Oncogene 25 (14): 2030-9. doi: . PMID 16301995.
- Valenta T, Lukas J, Doubravska L, et al. (2006). "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.". EMBO J. 25 (11): 2326-37. doi: . PMID 16724116.
- Stankovic-Valentin N, Verger A, Deltour-Balerdi S, et al. (2006). "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP.". FEBS J. 273 (13): 2879-90. doi: . PMID 16762039.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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