Vitamin-K-epoxide reductase (warfarin-insensitive)

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In enzymology, a vitamin-K-epoxide reductase (warfarin-insensitive) (EC 1.1.4.2) is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

Thus, the two substrates of this enzyme are 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone and oxidized dithiothreitol, whereas its two products are 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone and 1,4-dithiothreitol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a disulfide as acceptor. The systematic name of this enzyme class is 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithi othreitol oxidoreductase.

[edit] References

• IUBMB entry for 1.1.4.2
• BRENDA references for 1.1.4.2 (Recommended.)
• PubMed references for 1.1.4.2
• PubMed Central references for 1.1.4.2
• Google Scholar references for 1.1.4.2
• Mukharji I, Silverman RB (1985). "Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone". Proc. Natl. Acad. Sci. U. S. A. 82: 2713–7. doi:10.1073/pnas.82.9.2713. PMID 3857611. 

[edit] External links

The CAS registry number for this enzyme class is 97089-80-0.

• IUBMB entry for 1.1.4.2

• KEGG entry for 1.1.4.2

• BRENDA entry for 1.1.4.2

• NiceZyme view of 1.1.4.2

• EC2PDB: PDB structures for 1.1.4.2

• PRIAM entry for 1.1.4.2

• PUMA2 entry for 1.1.4.2

• IntEnz: Integrated Enzyme entry for 1.1.4.2

• MetaCyc entry for 1.1.4.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047058: vitamin-K-epoxide reductase (warfarin-insensitive)

• AMIGO entry for GO code 0047058: vitamin-K-epoxide reductase (warfarin-insensitive)

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1) 1.1.1 NAD/NADP acceptor Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase - L-threonine dehydrogenase 1.1.2 cytochrome acceptor Mannitol dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome c-553) 1.1.3 oxygen acceptor Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase 1.1.4 disulfide as acceptor Vitamin K epoxide reductase - Vitamin-K-epoxide reductase (warfarin-insensitive) 1.1.5 quinone/similar acceptor Quinoprotein glucose dehydrogenase 1.1.99 other acceptors Choline dehydrogenase