Choline dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a choline dehydrogenase (EC 1.1.99.1) is an enzyme that catalyzes the chemical reaction

choline + acceptor betaine aldehyde + reduced acceptor

Thus, the two substrates of this enzyme are choline and acceptor, whereas its two products are betaine aldehyde and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is choline:acceptor 1-oxidoreductase. Other names in common use include choline oxidase, choline-cytochrome c reductase, choline:(acceptor) oxidoreductase, and choline:(acceptor) 1-oxidoreductase. This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, PQQ.

[edit] References

• IUBMB entry for 1.1.99.1
• BRENDA references for 1.1.99.1 (Recommended.)
• PubMed references for 1.1.99.1
• PubMed Central references for 1.1.99.1
• Google Scholar references for 1.1.99.1
• K and Adachi O (1985). "Mammalian choline dehydrogenase is a quinoprotein". Agric. Biol. Chem. 49: 3623–3626. 
• EBISUZAKI K, WILLIAMS JN Jr (1955). "Preparation and partial purification of soluble choline dehydrogenase from liver mitochondria". Biochem. J. 60: 644–6. PMID 13249959. 
• Gadda G, McAllister-Wilkins EE (2003). "Cloning, expression, and purification of choline dehydrogenase from the moderate halophile Halomonas elongata". Appl. Environ. Microbiol. 69: 2126–32. PMID 12676692. 
• Takabe T (2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". J. Biol. Chem. 278: 4932–42. PMID 12466265. 

[edit] External links

The CAS registry number for this enzyme class is 9028-67-5.

• IUBMB entry for 1.1.99.1

• KEGG entry for 1.1.99.1

• BRENDA entry for 1.1.99.1

• NiceZyme view of 1.1.99.1

• EC2PDB: PDB structures for 1.1.99.1

• PRIAM entry for 1.1.99.1

• PUMA2 entry for 1.1.99.1

• IntEnz: Integrated Enzyme entry for 1.1.99.1

• MetaCyc entry for 1.1.99.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008812: choline dehydrogenase

• AMIGO entry for GO code 0008812: choline dehydrogenase

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1) 1.1.1 NAD/NADP acceptor Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase - L-threonine dehydrogenase 1.1.2 cytochrome acceptor Mannitol dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome c-553) 1.1.3 oxygen acceptor Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase 1.1.4 disulfide as acceptor Vitamin K epoxide reductase - Vitamin-K-epoxide reductase (warfarin-insensitive) 1.1.5 quinone/similar acceptor Quinoprotein glucose dehydrogenase 1.1.99 other acceptors Choline dehydrogenase